Abstract： Objective： Based on network pharmacology and molecular docking technology， the effect and mechanism of action of Niaoshiqing Granules in the treatment of urinary stones were discussed. Methods： The main active ingredients of Niaoshiqing Granules and their corresponding target proteins， as well as urinary stones-related genes，were screened，and intersection genes were selected. A protein-protein interaction （PPI） network analysis was constructed using STRING database. Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analyses of cross-targets were performed using R language. A Chinese medicine-active ingredient-targetdisease interaction network was constructed. AutoDockTools and PyMOL were used for molecular docking and visualization. Results： Network pharmacology analysis revealed 238 active ingredients and 410 potential targets. GO enrichment analysis yielded 2 626 GO entries. KEGG enrichment analysis yielded 164 signaling pathways. Molecular docking showed that the main active ingredients of Niaoshiqing Granules in the treatment of urinary stones were baicalein，luteolin，kaempferol，isorhamnetin and quercetin，which had good binding affinity with core urinary stones targets， including protein kinase B （AKT1）， signal transducer and activator of transcription 3 （STAT3）， tumor protein p53 （TP53）， transcription factor AP-1 subunit c-Jun （JUN）， B-cell lymphoma-2 protein （BCL2） and estrogen receptor α （ESR1）. Conclusion：The treatment of urinary stones with Niaoshiqing Granules exhibits multipathway and multi-target characterisitics， potentially exerting therapeutic effects by down-regulating the tyrosine protein kinase JAK2/STAT3 （JAK2/STAT3）， nuclear factor κB pathway （NF- κB）， and phosphatidylinositol 3-kinase-protein kinase B pathway（ PI3K-AKT）.