Abstract： Objective： To explore the mechanism of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis in improving idiopathic interstitial pneumonia by network pharmacology and molecular docking technology， and to optimize the extraction process of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis. Methods：Active components of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis and their corresponding potential targets were screened using the HERB database. Genes related to idiopathic interstitial pneumonia were screened from the GeneCards and DisGeNET databases. Venny2.1 was used to obtain the intersection of active component targets and idiopathic interstitial pneumonia targets. Cytoscape 3.10.1 software was used for data visualization to obtain the active component-targetidiopathic interstitial pneumonia network diagram of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis. The String database was used to construct a protein-protein interaction （PPI） network， and the DAVID database was used for Gene Ontology （GO） function and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis of potential targets. AutoDock Tools 1.5.7 software was used for molecular docking and to evaluate the stability of protein binding，resulting in 3D binding models. Reference was made to the Pharmacopoeia of the People's Republic of China to determine the indicator components. An orthogonal experimental design was used， with ethanol multiple， ethanol concentration， time of extraction， and extraction times as influencing factors， and comprehensive score and extract yield as evaluation indicators， to determine the optimal extraction process of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis. Results：A total of 427 potential targets were screened，and 185 common targets were obtained by intersecting with 2 023 idiopathic interstitial pneumonia-related targets. GO function enrichment analysis showed that the biological processes regulated by Acanthopanacis Senticosi Radix et Rhizoma seu Caulis in improving idiopathic interstitial pneumonia mainly focused on the positive regulation of protein kinase B signaling， positive regulation of MAP kinase activity， protein serine/threonine/tyrosine kinase activity， and regulation of protein tyrosine kinase activity. KEGG pathway enrichment analysis indicated that Acanthopanacis Senticosi Radix et Rhizoma seu Caulis is involved in regulating multiple pathways，including the PI3K-Akt signaling pathway，Ras signaling pathway，MAPK signaling pathway，HIF-1 signaling pathway，and Rap1 signaling pathway. Protein interaction analysis identified five core genes：AKT1，GAPDH，SRC，EGFR，and STAT3. Molecular docking further verified the binding stability of the main active components of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis （eleutheroside B，eleutheroside E，isofraxidin，and sesamin） with these five core genes. The indicator components were determined to be eleutheroside B， sesamin， and isofraxidin. The optimal extraction process was determined to be extraction with eight times the amount of 60% ethanol， twice， each time for 180 minutes. Conclusion： The active components of Acanthopanacis Senticosi Radix et Rhizoma seu Caulis can mainly improve idiopathic interstitial pneumonia by acting on the AKT1， GAPDH，SRC，EGFR，and STAT3 genes to regulate the expression levels of cell cycle proteins and kinases or inhibit the production and release of inflammatory factors. The extraction process optimized through network pharmacology and molecular docking technology is reasonable，stable，and reproducible，providing a reference for subsequent in-depth research.