基于数据挖掘分析姜劲挺治疗岭南地区腰椎间盘突出症用药规律
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R681.5 + 3

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深圳市中医院3030计划项目(G3030202131)


Analysis on Medication Rules of JIANG Jinting in Treating Lumbar Disc Herniation in Lingnan Region Based on Data Mining
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    摘要:

    目的:基于数据挖掘分析姜劲挺教授治疗岭南地区腰椎间盘突出症的用药规律。方法:收集2018年 9月—2025年1月姜劲挺教授门诊诊治的腰椎间盘突出症的病例,采用Excel 2021录入处方信息,建立数据库, 并对药物使用频次、药性、药味、归经及功效进行统计分析,通过SPSS Modeler 18.0进行关联规则分析,使用 SPSS26.0进行层次聚类分析,再使用Cytoscape构建复杂网络。结果:共纳入4 155首处方,涉及中药257味, 药物使用总频次104 837次。药性以温为主,寒温并用;药味以甘、苦、辛为主;归经以肝、肺、脾、心、肾 居多,功效以补虚药为主。经关联规则分析获得,排名前3位的对药为乌药-杜仲、乌药-葛根、杜仲-葛根; 排名前3位的角药组合为乌药-葛根-杜仲、乌药-首乌藤-杜仲和乌药-首乌藤-葛根;经聚类分析获得3类药 物组合;经复杂网络分析构建的核心药物组合包括续断、杜仲、乌药、桑寄生、桂枝、黄芪、赤芍、当归、 地龙、枳壳、薤白、黄连、首乌藤、炙甘草等24味药物。结论:姜劲挺教授治疗岭南地区腰椎间盘突出症以 疏肝补肾药为主,辅以调气、通络类药,寒温并用,体现了根据岭南地区气候及文化特点,在“五脏皆可致腰 痛,非独肾也”的学术思想指导下的用药规律。

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    Abstract: Objective: To analyze the medication rules of Professor JIANG Jinting in treating lumbar disc herniation in Lingnan region based on data mining. Methods: The outpatient cases of patients with lumbar disc herniation diagnosed and treated by Professor JIANG from September 2018 to January 2025 were collected. Excel 2021 was used to input the prescription information. With an established database, the frequency, nature, flavors, meridian entries and effects of Chinese medicine were statistically analyzed. SPSS Modeler 18.0 was used for association rule analysis,SPSS26.0 for hierarchical cluster analysis, and Cytoscape for establishment of a complex network. Results:A total of 4 155 prescriptions were included,involving 257 kinds of Chinese medicine which were used for 104 837 times in total. The Chinese medicine was mainly warm in nature,and that in cold was used together;the flavors were mainly sweet,bitter and acrid;the meridian entries were mostly the liver,lung,spleen,heart and kidney,and the effect was for supplementing deficiency. According to the association rules analysis,the top three herbal pairs were Linderae Radix-Eucommiae Cortex, Linderae Radix-Puerariae Lobatae Radix, and Eucommiae Cortex-Puerariae Lobatae Radix; the top three triplet herbal combinations were Linderae Radix-Puerariae Lobatae Radix-Eucommiae Cortex, Linderae Radix-Polygoni Multiflori Caulis-Eucommiae Cortex and Linderae Radix- Polygoni Multiflori Caulis-Puerariae Lobatae Radix;three medicinal combinations were obtained by cluster analysis; the core medicinal combinations established by complex network analysis yielded 24 kinds of Chinese medicine including Dipsaci Radix, Eucommiae Cortex, Linderae Radix, Taxilli Herba, Cinnamomi Ramulus, Astragali Radix, Paeoniae Radix Rubra, Angelicae Sinensis Radix, Pheretima, Aurantii Fructus, Allii Macrostemonis Bulbus, Coptidis Rhizoma, Polygoni Multiflori Caulis, Glycyrrhizae Radix et Rhizoma Praeparata cum Melle . Conclusion:Professor JIANG Jinting mainly uses liver-soothing and kidney-tonifying Chinese medicine for lumbar disc herniation in Lingnan region,supplemented by qi-regulating and meridian-dredging Chinese medicine,and the combination use of cold and warm Chinese medicine. It reflects the medication rules under the guidance of the academic thought of “low back pain is caused by one of five viscera instead of kidney only” according to the climate and cultural characteristics of Lingnan region.

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姜艳玲,郭晋婵,指导:姜劲挺.基于数据挖掘分析姜劲挺治疗岭南地区腰椎间盘突出症用药规律[J].新中医,2025,57(16):1-6

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  • 在线发布日期: 2025-08-26
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