Abstract：Objective：To observe the effects of Tiaozhi Granules on blood lipids，immune function，and sex hormones in hormone receptor-positive postmenopausal breast cancer patients with damp-turbidity and blood stasis syndrome treated with Letrozole. Methods：A total of 60 cases of hormone receptor-positive postmenopausal breast cancer patients with damp-turbidity and blood stasis syndrome，who treated at Jinhua Hospital Affiliated to Zhejiang University School of Medicine from January 2023 to April 2024，were selected and divided into the control group and the treatment group according to the random number table method，with 30 cases in each group. Both groups received Letrozole as adjuvant endocrine therapy，and the treatment group was additionally treated with Tiaozhi Granules based on the treatment of the control group. Both groups were treated for 12 weeks. Blood lipid indicators including total cholesterol（TC）， triglycerides（TG）， high-density lipoprotein cholesterol（HDL -C）， low-density lipoprotein cholesterol（LDL-C），lipoprotein（a）Lp（a），apolipoprotein A（Apo A），apolipoprotein B（Apo B），T lymphocyte subsets（CD3 + ，CD4 + ，CD8 + ，CD4 + /CD8 + ），sex hormones [luteinizing hormone（LH），follicle-stimulating hormone （FSH）， estradiol（E2）]， tumor markers [carcinoembryonic antigen（CEA）， carbohydrate antigen 125（CA125）， carbohydrate antigen 153（CA153）]， and liver and kidney function indicators [alanine aminotransferase （ALT）， aspartateaminotransferase（AST），alkalinephosphatase（ALP），γ-glutamyltransferase（γ-GT），serumcreatinine（SCr）， blood urea nitrogen（BUN）] in the two groups were measured before and after treatment. Results：After treatment，the levels of TC，Lp（a），and Apo B in the two groups were increased when compared with those before treatment（P＜ 0.05）. The Apo A level in the control group was decreased when compared with that before treatment（P＜0.05）and LDL-C level was increased when compared with that before treatment（P＜0.05）. The levels of TC，LDL-C，Lp（a）， and Apo B in the treatment group were lower than those in the control group（P＜0.05），and the levels of HDL-C and Apo A were higher（P＜0.05）. The levels of CD3 + and CD4 + in the treatment group were increased when compared with those before treatment（P＜0.05），the level of CD3 + in the treatment group was higher than that in the control group （P＜0.05）. There were no significant differences in the comparison of sex hormone indicators，tumor markers，or liver and kidney function indicators between the two groups before and after treatment（P＞0.05）. Conclusion：Tiaozhi Granules can effectively improve blood lipid profiles and enhance immune function in hormone receptor-positive postmenopausal breast cancer patients with damp-turbidity and blood stasis syndrome treated with Letrozole，and the treatment is relatively safe.