Abstract：This article introduces Professor WU Biao's clinical experience in treating liver cancer based on the theory of "deficiency leading to accumulation." Professor WU Biao believes that "deficiency of both liver and spleen， and impaired qi transformation" is the root cause of liver cancer，marking the origin of deficiency；"phlegm and blood stasis interconnection，and internal generation of turbid toxins" is the key to the progression of liver cancer，marking the formation of accumulation. Professor WU emphasizes that in the treatment of liver cancer，both reinforcing healthy qi and eliminating pathogenic factors should be given equal importance. Guided by the theory of "deficiency leading to accumulation，" the treatment should focus on regulating the liver and spleen，restoring qi transformation functions， while resolving phlegm， removing blood stasis， and clearing turbid toxins， thereby achieving a comprehensive treatment of both the symptoms and the root cause.