Abstract：Objective：To observe the clinical effect of Chinese massage under State-Target Theory combined with ginger paste-interposed moxibustion in treating diarrhea with spleen-kidney yang deficiency syndrome. Methods：A total of patients with diarrhea due to spleen-kidney yang deficiency treated at Cixi Integrated Traditional Chinese and Western Medicine Medical and Health Group from March to September 2024 were selected and randomly divided into the treatment group and the control group using the random number table method，with 45 cases in each group. The treatment group received Chinese massage under State-Target Theory combined with ginger paste-interposed moxibustion，while the control group received copper-cup portable moxibustion. The clinical effects，immune function indicators [immunoglobulin（Ig）G，IgM，IgA]，and serum inflammatory factor levels [tumor necrosis factor-α（TNF-α）， interleukin（IL）-6，IL-8] were compared between the two groups before and after treatment. Results：After treatment， the total effective rate was 91.12%（41/45）in the treatment group and 64.45%（29/45）in the control group，the difference being significant（P＜0.05）. After treatment， the levels of IgM， IgG， and IgA were increased in both groups when compared with those before treatment，and the above levels in the treatment group were higher than those in the control group，differences being significant（P＜0.05）. After treatment，the levels of TNF-α，IL-6，and IL-8 were decreased in both groups when compared with those before treatment，and the above levels in the treatment group were lower than those in the control group，differences being significant（P＜0.05）. Conclusion：Chinese massage under State-Target Theory combined with ginger paste-interposed moxibustion significantly improves clinical outcomes in diarrhea with spleen-kidney yang deficiency syndrome， enhances immune function， and reduces systemic inflammatory responses.