加味生化汤治疗产后宫内组织物残留临床研究
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R271.43;R714.46

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浙江省医药卫生科技计划项目(2024ZJKY0277)


Clinical Study on Modified Shenghua Decoction for Retained Products of Conception
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    摘要:

    目的:观察加味生化汤治疗产后宫内组织物残留气虚血瘀证的临床疗效。方法:选取2022年11月—2024年 11月在杭州市拱墅区中医院治疗的96例产后宫内组织物残留气虚血瘀证患者,按随机数字表法分为对照组、 试验组各48例。对照组给予鲜益母草胶囊治疗,试验组给予加味生化汤治疗。2组均连续治疗2周。比较2组 临床疗效及清宫率,治疗前后中医证候积分、宫缩痛视觉模拟评分法(VAS) 评分、子宫内膜厚度、子宫三 径、宫内组织物残留面积、子宫动脉血流参数[阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(PSV)、 舒张末期流速(EDV)]。结果:治疗2周后,试验组总有效率95.65% (44/46),高于对照组80.43% (37/46) (P<0.05)。2组中医证候积分、宫缩痛VAS评分均较治疗前降低(P<0.05),试验组中医证候积分、宫缩痛 VAS评分均低于对照组(P<0.05)。2组子宫内膜厚度均较治疗前增厚(P<0.05),试验组子宫内膜厚于对照 组(P<0.05);2组子宫三径、宫内组织物残留面积均较治疗前缩小(P<0.05),试验组子宫三径、宫内组织 物残留面积均小于对照组(P<0.05)。2组RI、PI均较治疗前降低,试验组RI、PI均低于对照组(P<0.05); 2组PSV、EDV均较治疗前加快(P<0.05),试验组PSV、EDV均快于对照组(P<0.05)。试验组清宫率2.17% (1/46),低于对照组13.04%(6/46)(P<0.05)。结论:加味生化汤治疗产后宫内组织物残留气虚血瘀证疗效 好,可缓解症状,减轻宫缩痛,促进子宫复旧,改善子宫血液循环状态,降低清宫率。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Shenghua Decoction on retained products of conception with qi deficiency and blood stasis syndrome. Methods: A total of 96 patients with retained products of conception with qi deficiency and blood stasis syndrome who were treated in Hangzhou Gongshu District Hospital of Traditional Chinese Medicine from November 2022 to November 2024 were selected and divided into the control group and the trial group according to the random number table method,with 48 cases in each group. The control group was treated with Xian Yimucao Capsules, and the trial group was treated with modified Shenghua Decoction. Both groups were treated for two weeks continuously. The clinical effects and curettage rate, the traditional Chinese medicine syndrome scores, scores of Visual Analogue Scale(VAS)of uterine contraction pain, endometrial thickness, three uterine dimensions, area of retained products, and uterine artery blood flow parameters [resistance index(RI), pulsatility index(PI),peak systolic velocity(PSV)and end diastolic velocity(EDV)] before and after treatment were compared between the two groups. Results:After two weeks of treatment,the total effective rate was 95.65%(44/46) in the trial group,higher than that of 80.43%(37/46)in the control group(P<0.05). The traditional Chinese medicine syndrome scores and VAS scores of uterine contraction pain in the two groups were reduced when compared with those before treatment(P<0.05), and the above scores in the trial group were lower than those in the control group(P< 0.05). The endometrial thickness of the two groups was thickened when compared with that before treatment(P<0.05), and the endometrial thickness in the trial group was thicker than that in the control group(P<0.05);the three uterine dimensions and the residual area of retained products in the two groups were decreased when compared with those before treatment(P<0.05),and the three diameters of uterus and the area of retained products in the trial group were less than those in the control group(P<0.05). The RI and PI in the two groups were down-regulated when compared with those before treatment,and the RI and PI in the trial group were lower than those in the control group(P<0.05);the PSV and EDV in the two groups were elevated when compared with those before treatment(P<0.05),and PSV and EDV in the trial group were faster than those in the control group(P<0.05). The curettage rate was 2.17%(1/46)in the trial group, lower than that of 13.04%(6 / 46)in the control group(P<0.05). Conclusion: Modified Shenghua Decoction can improve the curative effect on retained products of conception with qi deficiency and blood stasis syndrome,relieve symptoms,reduce uterine contraction pain,promote the uterine involution,improve uterine blood circulation,and reduce the curettage rate.

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杨氏平,刘松花,盛晓园.加味生化汤治疗产后宫内组织物残留临床研究[J].新中医,2025,57(17):15-20

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  • 在线发布日期: 2025-09-05
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