Abstract： Objective： To observe the therapeutic effect of Huayu Xiaozheng Prescription combined with an infrared therapy device in treating chronic pelvic inflammatory disease（CPID）of damp-heat-stasis stagnation type. Methods：A total of 60 patients with CPID of damp-heat-stasis stagnation type treated at the Department of Traditional Chinese Medicine， Yuhuan Second People's Hospital from June 2023 to June 2024 were selected and divided into a control group and an observation group，with 30 cases in each group，using a random number table method. The control group received conventional western medicine treatment，while the observation group was treated with Huayu Xiaozheng Prescription combined with an infrared therapy device on the basis of the control group. Clinical efficacy and the incidence of adverse reactions were compared between the two groups，as well as changes in pain of Visual Analogue Scale （VAS）scores， traditional Chinese medicine syndrome scores， pelvic ultrasound results， hemorheological indicators [whole blood viscosity（high shear and low shear）， fibrinogen（FIB）， and erythrocyte sedimentation rate（ESR）]， and serum inflammatory markers [tumor necrosis factor-α（TNF-α）， interleukin-6（IL-6）， highsensitivity C-reactive protein（hs-CRP）， and transforming growth factor-β1（TGF-β1）] before and after treatment. Results：The total effective rate of clinical efficacy in the observation group was 93.33%（28/30），higher than that in the control group at 70.00%（21/30），with a statistically significant difference between the two groups（P＜0.05）. After treatment，traditional Chinese medicine syndrome scores and VAS scores decreased in both groups compared to before treatment（P＜0.05）， with the observation group achieving lower scores than the control group（P＜0.05）. After treatment，pelvic effusion decreased and the volume of inflammatory masses shrank in both groups compared to before treatment（P＜0.05），with the observation group showing less pelvic effusion and smaller inflammatory masses than the control group（P＜0.05）. After treatment， ESR， FIB， and whole blood viscosity（high shear， low shear）levels decreased in both groups compared to before treatment（P＜0.05）， with the observation group achieving lower levels than the control group（P＜0.05）. After treatment，hs-CRP，IL-6，and TNF-α levels decreased while TGF-β1 levels increased in both groups compared to before treatment（P＜0.05）， with the observation group having lower levels of hs-CRP，IL-6，and TNF-α and higher level of TGF-β1 than the control group（P＜0.05）. The incidence of adverse reactions was 13.33%（4/30）in the control group and 10.00%（3/30）in the observation group，with no statistically significant difference between the two groups （P＞0.05）. Conclusion： The combination of Huayu Xiaozheng Prescription and an infrared therapy device is effective in treating CPID of damp-heat-stasis stagnation type. It can alleviate clinical symptoms， reduce pelvic effusion， shrink inflammatory masses， lower pain levels and systemic inflammatory responses，and promote blood circulation，with high safety.