Abstract：Objective：To observe the curative effect of Honghua Ruyi Pills combined with antibiotics on chronic pelvic inflammatory disease（CPID）and its effects on immune cells and serum inflammatory factors. Methods：A total of 98 cases of CPID patients treated at the Department of Obstetrics and Gynecology，Taizhou Central Hospital/Taizhou University Hospital from January 2024 to September 2024 were selected and divided into the control group and the trial group according to the random number table method，with 49 cases in each group. Both groups received Levofloxacin Tablets；the control group was given the oral administration of placebo Vitamin C Tablets，and the trial group was given the oral administration of Honghua Ruyi Pills. The clinical symptom disappearance time， the incidence of adverse reactions， and the recurrence rates were compared between the two groups. Changes in Visual Analogue Scale（VAS） scores for pain， T cell subset indicators（CD3+ ， CD4+ ， CD8+ ， CD4+/CD8+）， and serum inflammatory factors [interleukin-2（IL -2）， tumor necrosis factor - α（TNF - α）， C-reactive protein（CRP）] in the two groups were compared before and after treatment. Results：The disappearance time of clinical symptoms such as abnormal vaginal discharge，abdominal pain，lower abdominal distension，and vulvar itching in the trial group was shorter than that in the control group（P＜0.05）. After treatment，VAS scores in the two groups were decreased when compared with those before treatment（P＜0.05），with the trial group showing lower VAS score than the control group（P＜0.05）. At 30 and 90 days after treatment，the levels of CD3+，CD4+，and CD4+/CD8+ in the two groups were increased when compared with those before treatment（P＜0.05），and CD8+ levels were decreased（P＜0.05）. The trial group had higher levels of CD3+ ， CD4+ ， and CD4+/CD8+ and lower CD8+ level than the control group（P＜0.05）. At 30 and 90 days after treatment，IL-2 levels in the two groups were increased when compared with those before treatment（P＜0.05），and the levels of TNF-α and CRP were reduced when compared with those before treatment（P＜0.05）. The trial group had higher IL-2 level and lower levels of TNF-α and CRP than the control group（P＜0.05）. During the treatment period， the incidence of adverse reactions was 6.12%（3/49）in the control group and 8.16%（4/49）in the trial group，with no significant difference between the two groups（P＞0.05）. After three-month follow-up，the recurrence rate was 16.33% （8/49）in the control group and 4.08%（2/49）in the trial group，with a significant difference between the two groups （P＜0.05）. Conclusion： Honghua Ruyi Pills combined with antibiotics has a good curative effect in treating CPID， which can significantly improve immune cell levels and reduce serum inflammatory factor levels and recurrence risk， with high safety.