通元针法联合常规西药治疗老年脑卒中意识障碍临床研究
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R743.3;R277.7

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国家自然科学基金面上项目(81974582);2022年广东省省级妇幼保健机构中医药工作示范基地建设项目(粤卫办妇幼函〔2021〕 41号);2022年佛山市“十四五”重点专科建设项目


Clinical Study on Tongyuan Acupuncture Combined with Conventional Western Medi⁃ cine for Consciousness Disorders in Elderly Stroke
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    摘要:

    目的:观察通元针法联合常规西药治疗老年脑卒中意识障碍的疗效。方法:选取2023年6月—2024年 6月广州中医药大学附属南海妇产儿童医院收治的90例老年脑卒中意识障碍恢复早期患者,按随机数字表法分 为对照组及观察组各45例。对照组采用常规西药治疗,观察组采用通元针法联合常规西药治疗。比较2组临床 疗效,比较2组治疗前后神经因子指标值[脑源性神经细胞营养因子(BDNF)、神经元特异性烯醇化酶(NSE)]、 脑血流动力学指标值[平均血流速度(Vm)、收缩期最大血流速度(Vs)]、意识及神经功能[格拉斯哥昏迷 量表(GCS)、简易智能量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)] 评分的变化。结果:观 察组临床疗效总有效率为88.89%(40/45),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05)。治 疗后,2组BDNF水平均较治疗前提升(P<0.05),NSE水平均较治疗前下降(P<0.05);观察组BDNF水平高 于对照组(P<0.05),NSE 水平低于对照组(P<0.05)。治疗后,2 组大脑动脉Vm、Vs 值均较治疗前提升 (P<0.05),观察组大脑动脉Vm、Vs值均高于对照组(P<0.05)。治疗后,2组GCS、MMSE评分均较治疗前 提升(P<0.05),NIHSS 评分较治疗前下降(P<0.05);观察组GCS、MMSE 评分高于对照组(P<0.05), NIHSS评分低于对照组(P<0.05)。结论:通元针法联合常规西药治疗老年脑卒中意识障碍疗效较好,能改善 脑血流动力学指标值,减轻脑细胞损伤,促进认知功能恢复。

    Abstract:

    Abstract: Objective: To observe the efficacy of Tongyuan acupuncture combined with conventional western medicine in treating consciousness disorders in elderly stroke. Methods:A total of 90 elderly patients with early-stage post-stroke consciousness disorders treated at Nanhai Maternity and Child Healthcare Hospital Affiliated to Guangzhou University of Chinese Medicine from June 2023 to June 2024 were randomly divided into the control group and the observation group, with 45 cases each. The control group received conventional western medicine, while the observation group received additional Tongyuan acupuncture. Clinical efficacy was compared between the two groups. Changes in neurotrophic factors [brain-derived neurotrophic factor(BDNF), and neuron-specific enolase(NSE)], cerebral hemodynamics [mean blood flow velocity(Vm), and peak systolic velocity(Vs)], and consciousness / neurological function [Glasgow Coma Scale(GCS),Mini-Mental State Examination(MMSE),and National Institutes of Health Stroke Scale(NIHSS)] were evaluated before and after treatment. Results: The total effective rate was 88.89%(40/45)in the observation group and 71.11%(32/45)in the control group(P<0.05). After treatment,both groups showed increased BDNF(P<0.05)and decreased NSE(P<0.05);the BDNF level in the observation group was higher than that in the control group(P<0.05),and NSE level was lower(P<0.05). After treatment,cerebral artery Vm and Vs values improved in both groups(P<0.05), showing greater improvement in the observation group (P<0.05). After treatment, GCS and MMSE scores increased while NIHSS scores decreased in both groups(P< 0.05), with higher GCS and MMSE scores(P<0.05)and lower NIHSS score(P<0.05)in the observation group. Conclusion: Tongyuan acupuncture combined with conventional western medicine demonstrates good efficacy for consciousness disorders in elderly stroke by improving cerebral hemodynamics, reducing brain cell damage, and promoting cognitive recovery of patients.

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刘群,杨光林,林耀展,周俊亮.通元针法联合常规西药治疗老年脑卒中意识障碍临床研究[J].新中医,2025,57(17):105-109

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  • 在线发布日期: 2025-09-05
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