中医外治法干预慢性咳嗽疗效Meta 分析
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R244;R273

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浙江省中医药科技计划项目(2025ZL305)


Meta-Analysis of the Curative Effect of Chinese Medicine External Treatments for Chronic Cough
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    摘要:

    目的:系统评价中医外治法干预慢性咳嗽患者的疗效。方法:计算机检索中国知网、万方、中国 生物医学文献数据库、维普、Cochrane Library、Embase、PubMed、Web of Science等数据库中有关中医外治法 治疗慢性咳嗽的随机对照研究,检索时限为从建库至2025年4月。由2名研究员独立进行文献检索、筛选、数 据提取及质量评价,运用RevMan 5.3软件对最终所纳入研究进行Meta分析。结果:最终纳入27篇文献,2 720例 病例。Meta分析结果显示,干预组咳嗽症状积分低于对照组[MD=-1.05,95%CI(-1.45,-0.65),P<0.000 01], 亚组分析考虑干预时间为异质性来源,干预2周组[MD=-1.29,95%CI(-1.40,-1.19),P<0.000 1]、干预 3周组[MD=-0.73,95%CI(-1.14,-0.32),P<0.01] 效果显著。干预组炎症因子C-反应蛋白(CRP)[MD= -5.22,95%CI(-7.74,-2.69),P<0.000 01]、TNF-α[MD=-0.15,95%CI(-0.19,-0.11),P<0.000 01] 水平 低于对照组,亚组分析发现CRP结果的异质性考虑与中医病因病机有关,复合证型组(MD=-10.94) 和外邪袭 肺组(MD=-1.36) 效果显著(P<0.000 01),内邪扰肺组排除疾病急性期研究后异质性明显降低;肿瘤坏死因 子-α(TNF-α) 敏感性分析考虑疾病不同阶段为异质性的来源,排除疾病急性期研究后异质性明显降低且结果稳 健[MD=-0.15,95%CI(-0.19,-0.11),P<0.000 01]。干预组有效率高于对照组[OR=3.94,95%CI(3.08,5.05), P<0.000 01],不良反应发生率低于对照组[OR=0.22,95%CI(0.07,0.65),P<0.01]。干预组生活质量高于对 照组[MD=2.01,95%CI (0.81,3.20),P<0.05],敏感性分析剔除问卷维度差异的研究后亚组分析发现, 外邪袭肺组[MD=2.14,95%CI (1.52,2.77),P<0.000 01] 结果显著,但内邪扰肺组[MD=1.97,95%CI (-0.64,4.58),P=0.14] 组内差异不具有统计学意义。结论:中医外治法干预慢性咳嗽疗效明确,可有效减 轻患者咳嗽症状,提高生活质量,同时不良反应少,安全性高,但未来仍需要更多严谨高质量的随机对照试 验验证其结果的可靠性。

    Abstract:

    Abstract:Objective:To systematically evaluate the efficacy of Chinese medicine external treatments for patients with chronic cough. Methods: Computerized searches were conducted in databases including China National Knowledge Infrastructure(CNKI),Wanfang,China Biology Medicine disc(CBM),VIP,Cochrane Library,Embase, PubMed, and Web of Science for randomized controlled trials on Chinese medicine external treatments for chronic cough,with the search period ranging from the inception of the databases to April 2025. Two researchers independently conducted literature searches, screening, data extraction, and quality assessment. Meta-analysis was performed on the included studies using RevMan 5.3 software. Results:A total of 27 articles were included,covering 2 720 cases. The Meta-analysis results showed that the cough symptom scores in the intervention group were lower than those in the control group [MD=-1.05,95%CI(-1.45,-0.65),P<0.000 01]. Subgroup analysis considered intervention time as a source of heterogeneity,with significant effects in the 2-week intervention group [MD=-1.29,95%CI(-1.40,-1.19), P<0.000 1] and the 3-week intervention group [MD=- 0.73, 95%CI(- 1.14, - 0.32), P<0.01]. The levels of inflammatory factors CRP [MD=-5.22, 95%CI(-7.74, -2.69), P<0.000 01] and TNF-α [MD=-0.15, 95%CI (-0.19,-0.11),P<0.000 01] were lower in the intervention group than in the control group. Subgroup analysis found that the heterogeneity in CRP results was related to Chinese medicine etiology and pathogenesis,with significant effects in the composite syndrome group(MD=-10.94)and the external pathogens invading the lung group(MD=-1.36)(both P<0.000 01). After excluding studies in the acute phase of the disease, the heterogeneity in the internal pathogens disturbing the lung group was significantly reduced. Sensitivity analysis for TNF-α considered different disease stages as a source of heterogeneity, and after excluding studies in the acute phase of the disease, the heterogeneity was significantly reduced and the results were robust [MD=-0.15,95%CI(-0.19,-0.11),P<0.000 01]. The effective rate was higher in the intervention group than in the control group [OR=3.94,95%CI(3.08,5.05),P<0.000 01], and the incidence of adverse reactions was lower in the intervention group [OR=0.22,95%CI(0.07,0.65),P<0.01]. The quality of life was higher in the intervention group than in the control group [MD=2.01,95%CI(0.81,3.20),P< 0.05]. After excluding studies with differences in questionnaire dimensions,subgroup analysis found significant results in the external pathogens invading the lung group [MD=2.14,95%CI(1.52,2.77),P<0.000 01],but no significant difference within the internal pathogens disturbing the lung group [MD=1.97, 95%CI(- 0.64, 4.58), P=0.14]. Conclusion: Chinese medicine external treatments have a clear efficacy in treating chronic cough, effectively alleviating cough symptoms,improving quality of life,with few adverse reactions and high safety. However,more rigorous and high-quality randomized controlled trials are still needed in the future to verify the reliability of the results.

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胡祝红,施守芳,胡晓涵.中医外治法干预慢性咳嗽疗效Meta 分析[J].新中医,2025,57(17):169-177

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  • 在线发布日期: 2025-09-05
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