Abstract：Objective：To analyze the therapeutic mechanisms of Anluo Huaxian Pills for chronic hepatitis B（CHB） using network pharmacology and molecular docking. Methods：Active components and targets of Anluo Huaxian Pills were screened via Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）， HERB，A Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine（BATMAN-TCM）， PubChem， Similarity Ensemble Approach（SEA）， and Swiss Target Prediction databases. CHB-related genes were identified by analyzing the GSE121248 dataset from Gene Expression Omnibus（GEO），integrated with genes from The Human Gene Database（GeneCards），Online Mendelian Inheritance in Man（OMIM），Comparative Toxicogenomics Database（CTD）， Therapeutic Target Database（TTD）， and GEO datasets. Compound-target-disease and proteinprotein interaction（PPI）networks were constructed using Cytoscape 3.7.2. software；Gene Ontology（GO）functional analysis and Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway enrichment analysis were performed with the Database for Annotation，Visualization，and Integrated Discovery（DAVID）. Finally，Autodock software was used to perform molecular docking to investigate the interaction mechanisms between key components and core targets. Results： The analysis identified 110 bioactive components and 1 059 targets of Anluo Huaxian Pills，with 372 overlapping targets among 2 176 CHB-related genes. By constructing a compound-target-disease network and performing PPI network topology analysis，20 hub targets were identified，e.g.，glyceraldehyde-3-phosphate dehydrogenase（GAPDH），tumor necrosis factor（TNF），serine / threonine kinase 1（AKT1），interleukin-6（IL-6）， tumor protein p53（TP53）and interleukin-1β（IL-1β）. GO enrichment analysis yielded 1 375 entries involving protein binding， kinase activity， apoptotic regulation， transcriptional positive regulation of RNA polymerase Ⅱ promoter， and inflammatory response. KEGG analysis highlighted 122 enriched pathways， predominantly antiviral pathways， inflammation / immunity modulation， cellular proliferation / apoptosis / autophagy， and lipid metabolism. Key components like lumbrokinase capsules，quercetin，kaempferol，ecdysone，luteolin，and N6-isopentenyladenosine exhibited strong binding to core targets like GAPDH， TNF， AKT1， IL-6， and TP53. Conclusion： Anluo Huaxian Pills may exert comprehensive therapeutic effects on CHB through key active components such as lumbrokinase capsules， which act on targets like GAPDH. This regulation involves multiple pathways，including antiviral activity，inflammation and immune response， cell proliferation，apoptosis and autophagy，and lipid metabolism.