Abstract：Objective：To analyze the medication rules of renowned Chinese medicine practioner ZHANG Qin in the treatment of peri-in vitro fertilization-embryo transfer（IVF-ET）technology through data mining．Methods：Formulas forpatientswithperi-IVF-ETtreatedbyProfessorZHANGQininoutpatientclinicsfromJanuary 2021toJanuary2024were collected and sorted． A database was established using Microsoft Office Excel． The "Medical Case Statistics" in the "Statistical Report" module of Traditional Chinese Medicine Inheritance Support System V2.5 was used for syndrome statistics，medicinal frequency statistics，natures，flavors，and channel entries statistics．The "Formula Analysis" in the "Data Analysis" module was applied for statistical analysis of formula composition rules and new formula analysis， with network visualization realized． Results： A total of 226 formulas were included， including 98 before surgery， 16 in the down-regulation period，22 in the superovulation period，39 in the pre-transplantation period，and 51 in the post-transplantation period， involving 148 kinds of Chinese herbal medicines． Syndromes before surgery and in the pre-transplantation period were mainly kidney deficiency and blood stasis； those in the down-regulation period were mainly heart-kidney yin deficiency；those in the superovulation period were mainly liver-kidney deficiency；and those in the post-transplantation period were mainly spleen-kidney deficiency．Before surgery，16 Chinese herbal medicines had a frequency≥ 32 times，with the top eight being Angelicae Sinensis Radix，fried Paeoniae Radix Alba，Cuscutae Semen，Dioscoreae Rhizoma，Citri Reticulatae Pericarpium，Cistanches Herba，Chuanxiong Rhizoma，and Epimedii Folium．Inthedown-regulationperiod，10Chineseherbalmedicineshadafrequency≥10times；inthesuperovulation period， 12 had a frequency≥12 times； in the pre-transplantation period， 11 had a frequency≥20 times； and in the posttransplantation period，14 had a frequency≥34 times．Cluster analysis obtained new prescriptions，eight for pre-surgery and eight for post-transplantation respectively．Conclusion：Professor ZHANG Qin mainly uses kidney-tonifying and stasis-removing medicines before peri-IVF-ET treatment， combined with spleen-strengthening and qi-regulating medicines； during the procedure， treatment is administered by stages， and after transplantation， spleenstrengthening and kidney-supplementing medicines，and qi-boosting and fetus-stabilizing medicines are mainly used.