Abstract：Objective：To observe the clinical effect of Tongtian Oral Liquid combined with conventional western medicine in the treatment of acute cerebral infarction（ACI）with qi deficiency and blood stasis syndrome．Methods： A total of 104 ACI patients with qi deficiency and blood stasis syndrome treated at Xuchang Central Hospital from January 2022 to December 2023 were divided into the integrated Chinese-western medicine group and conventional group according to the random number table method，52 cases in each group．The conventional group was treated with conventional treatment of Aspirin Enteric-Coated Tablets and Butylphthalide Soft Capsules， and the integrated Chinese-western medicine group was additionally treated with Tongtian Oral Liquid based on the conventional treatment． The total effective rate，neurological impairment [National Institute of Health Stroke Scale（NIHSS）scores]，traditional Chinese medicine syndrome scores，hemodynamic parameters [mean blood flow velocity（Vm）of middle cerebral artery （MCA）， resistance index（RI）]， neural factors [myelin basic protein（MBP）， central nervous specific protein（S- 100β），neuron-specific enolase（NSE）]，Barthel Index（BI），and safety were all compared between the two groups. Results： The total effective rate was 88.46%（46/52）in the integrated Chinese-western medicine group ， and was 73.08%（38/52）in the conventional group，the difference being significant（P＜0.05）．After treatment，both groups showed reduced NIHSS and traditional Chinese medicine syndrome scores（P＜0.05）， with greater reductions in the integrated Chinese -western medicine group（P＜0.05）． After treatment， the levels of MCA-Vm in both groups increased compared with those before treatment（P＜0.05），and the levels of MCA-RI decreased compared with those before treatment（P＜0.05）；the level of MCA-Vm in the integrated Chinese-western medicine group was higher than that in the conventional group， and the value of MCA-RI was lower than that in the conventional group， differences being significant（P＜0.05）． The levels of MBP， S-100β， and NSE decreased in both groups compared with those before treatment（P＜0.05），with the above levels lower in the integrated Chinese-western medicine group（P＜0.05）． The BI scores improved in both groups（P＜0.05），with higher BI scores in the integrated Chinese-western medicine group（P＜0.05）．The incidence of adverse reactions in the integrated Chinese-western medicine group was 5.77%（3/ 52），lower than that of 15.38%（8/52）in the conventional group，there being no significant difference（P＞0.05）． Conclusion：The combination of Tongtian Oral Liquid with conventional western medicine demonstrates superior effect in treating ACI with qi deficiency and blood stasis syndrome，improving neurological function，cerebral hemodynamics， and daily living activities with higher safety.