柴芩温胆宣肺汤结合咽部肌肉训练治疗痰热内蕴型阻塞性睡眠呼吸暂停低通气综合征临床研究
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R276.1

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温州市基础性公益科研项目(Y20240339)


Clinical Study on Chaiqin Wendan Xuanfei Decoction Combined with Pharyngeal Muscle Training for Obstructive Sleep Apnea-Hypopnea Syndrome of Phlegm-Heat Accumulation Type
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    摘要:

    目的:观察柴芩温胆宣肺汤结合咽部肌肉训练治疗痰热内蕴型阻塞性睡眠呼吸暂停低通气综合征 (OSAHS) 的临床疗效。方法:选取2024年1—12月于温州市中西医结合医院就诊的96例痰热内蕴型OSAHS 患者,按随机数字表法分为2组,每组48例。对照组采用咽部肌肉训练治疗,观察组在对照组治疗方案的基础 上口服柴芩温胆宣肺汤治疗。评估比较2组OSAHS患者治疗前后多导睡眠图监测指标、艾普沃斯嗜睡量表评 分(ESS)、鼾声量表(SS) 及匹兹堡睡眠质量指数(PSQI),比较2组OSAHS患者的临床疗效。结果:与对照 组比较,治疗后观察组睡眠呼吸暂停低通气指数(AHI)、ESS、SS及PSQI评分降低,差异均有统计学意义(P < 0.05);观察组夜间最低动脉血氧饱和度升高,最长呼吸暂停时间缩短,差异均有统计学意义(P <0.05)。观 察组临床总有效率85.42%(41/48),对照组66.67%(32/48),2组比较,差异有统计学意义(P <0.05),观察 组优于对照组。结论:柴芩温胆宣肺汤结合咽部肌肉训练可改善痰热内蕴型OSAHS患者睡眠时通气量,缓解 打鼾、嗜睡等临床症状,提高睡眠质量。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Chaiqin Wendan Xuanfei Decoction combined with pharyngeal muscle training on obstructive sleep apnea-hypopnea syndrome(OSAHS) of phlegm-heat accumulation type. Methods: A total of 96 cases of patients with OSAHS of phlegm-heat accumulation type who were treated at Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from January to December 2024 were selected and divided into two groups according to the random number table method,with 48 cases in each group.The control group received pharyngeal muscle training, and the observation group received the oral administration of Chaiqin Wendan Xuanfei Decoction in addition to the pharyngeal muscle training. Polysomnography monitoring indicators, Epworth Sleepiness Scale(ESS)scores, Snoring Scale(SS)scores, and Pittsburgh Sleep Quality Index (PSQI)scores were evaluated and compared before and after treatment in the two groups. The clinical effects were compared between the two groups. Results: Compared with the control group, the observation group showed significant improvements after treatment, with reductions in apnea-hypopnea index(AHI), ESS, SS, and PSQI scores(P<0.05); the observation group had a significant increase in the minimum arterial oxygen saturation and a reduction in the maximum apnea duration(P<0.05). The overall clinical efficacy rate was 85.42%(41/48)in the observation group,higher than 66.67%(32/48)in the control group,with a significant difference(P<0.05).The clinical effect in the observation group was better that that in the control group.Conclusion:Chaiqin Wendan Xuanfei Decoction combined with pharyngeal muscle training can improve ventilation during sleep,alleviate clinical symptoms such as snoring and daytime sleepiness, and enhance sleep quality in patients with OSAHS of phlegm-heat accumulation type.

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阎晓琳,麻琼钒.柴芩温胆宣肺汤结合咽部肌肉训练治疗痰热内蕴型阻塞性睡眠呼吸暂停低通气综合征临床研究[J].新中医,2025,57(18):54-58

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  • 在线发布日期: 2025-09-25
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