温肾化瘀分期疗法治疗子宫腺肌病临床研究
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R737.33

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绍兴市卫生健康科技计划项目(2022KY111)


Clinical Study on Treatment of Uterine Adenomyosis with Kidney-Warming and Stasis-Dissolving Therapy Based on Menstrual Phases
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    摘要:

    目的:观察温肾化瘀分期疗法治疗子宫腺肌病的临床疗效。方法:收集2022年10月—2024年9月嵊 州市中医院妇科门诊治疗的100例子宫腺肌病患者,采用区组随机化方法随机分为试验组与对照组各50例。对 照组给予少腹逐瘀汤治疗,试验组给予温肾化瘀分期疗法(围月经期经前3天起至月经干净服用化瘀方,经间 期服用温肾方) 治疗。治疗3个月经周期,比较2组治疗前后血液流变学指标[全血高切(200/s) 黏度、全血低 切黏度(1/s)、血浆黏度] 水平、痛经程度评分、中医证候评分、疼痛视觉模拟评分法(VAS) 评分、子宫体 积大小、糖类抗原125 (CA125) 水平。结果:治疗后,试验组总有效率88.00% (44/50),对照组为78.00% (39/50),2 组比较, 差异无统计学意义(P>0.05)。试验组愈显率52.00% (26/50), 对照组为32.00% (16/50),2组比较,差异有统计学意义(P<0.05)。2组全血高切黏度、全血低切黏度、血浆黏度水平较治 疗前均降低(P<0.05),试验组3项指标水平均低于对照组(P<0.05)。治疗后,2组痛经程度评分、中医 证候评分、VAS评分较治疗前均降低(P<0.05),且试验组3项评分均低于对照组(P<0.05)。治疗后,试 验组子宫体积较治疗前缩小(P<0.05),且小于对照组(P<0.05);对照组子宫体积治疗前后比较,差异 无统计学意义(P>0.05)。治疗后,2 组CA125 水平均较治疗前降低(P<0.05),且试验组低于对照组 (P<0.05)。结论:温肾化瘀分期疗法治疗子宫腺肌病可有效缓解临床症状,减轻疼痛,缩小子宫体积,改善 血液流变学状态及血清CA125水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of kidney-warming and stasis-dissolving therapy based on menstrual phases in treating uterine adenomyosis.Methods:A total of 100 uterine adenomyosis patients treated at the Inpatient Department of Gynecology, Shengzhou Traditional Chinese Medicine Hospital from October 2022 to September 2024 were collected and randomly divided into a trial group and a control group,with 50 cases in each group using block randomization.The control group was treated with Shaofu Zhuyu Decoction,while the trial group received kidney-warming and stasis-dissolving therapy(administering Huayu Prescription from three days before menstruation until the end of the menstrual period and kidney-warming Prescription during the intermenstrual period).The treatment lasted for three menstrual cycles.Hemorheological parameters [whole blood high shear viscosity(200/s),whole blood low shear viscosity(1 / s), and plasma viscosity], dysmenorrhea severity scores, traditional Chinese medicine syndrome scores, Visual Analogue Scale(VAS)for pain, uterine volume, and carbohydrate antigen 125(CA125) levels were compared before and after treatment between the two groups.Results:After treatment,the total effective rate was 88.00%(44/50)in the trial group and 78.00%(39/50)in the control group, with no significance in the difference(P>0.05).The cured and markedly improved rate was 52.00% (26/50) in the trial group and 32.00% (16/50) in the control group, with significance in the difference(P<0.05).In both groups, whole blood high shear viscosity, whole blood low shear viscosity,and plasma viscosity were decreased compared to before treatment(P<0.05),with the trial group showing lower levels in all three parameters(P<0.05). Dysmenorrhea severity scores, traditional Chinese medicine syndrome scores,and VAS scores were decreased in both groups after treatment(P<0.05),with the trial group having lower scores than the control group(P<0.05).After treatment,the uterine volume in the trial group decreased compared to before treatment(P<0.05) and was smaller than that of the control group(P<0.05). In contrast,no statistically significant difference was observed in the control group before and after treatment(P>0.05). CA125 levels in both groups reduced compared to before treatment(P<0.05),with the trial group showing lower levels than the control group(P<0.05). Conclusion: Kidney-warming and stasis-dissolving therapy based on menstrual phases can effectively alleviate clinical symptoms of uterine adenomyosis, reduce pain, shrink uterine volume, and improve hemorheological and serum CA125 levels.

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吕双,陈剑红.温肾化瘀分期疗法治疗子宫腺肌病临床研究[J].新中医,2025,57(18):65-69

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  • 在线发布日期: 2025-09-25
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