中医外治法辅助治疗小儿外感发热有效性和安全性的网状Meta 分析
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R244

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广东省中医急症研究重点实验室(2023B1212060062)


A Network Meta-Analysis on Efficacy and Safety of Chinese Medicine External Treatment for Pediatric Exogenous Fever
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    摘要:

    目的:运用网状Meta分析方法(NMA) 系统评价中医外治法辅助治疗小儿外感发热的有效性和安 全性。方法:计算机检索PubMed、Embase、Cochrane图书馆、中国国家知识基础设施(CNKI)、万方数据 库、VIP和中国生物医学文献数据库中有关中医外治法治疗小儿外感发热的随机对照试验(RCTs),确立相关 检索词,检索日期为2010年1月—2023年6月。由2名研究者根据设定好的标准独立筛选文献、提取数据并评 价纳入研究的偏倚风险,采用R-4.3.1软件进行网状Meta分析。结果:共纳入30篇RCTs研究,样本量5 888例, 涉及19种干预措施。网状Meta分析结果显示,临床有效率方面,与单纯常规基础治疗比较,单纯常规基础治 疗联合灌肠、贴敷、放血、药浴、推拿等中医外治法或单独使用灌肠+放血、放血+推拿、药浴+推拿、刮痧、 灌肠、药浴、推拿、放血+足浴、药浴+针灸、足浴、放血、贴敷的疗效均优于单纯常规基础治疗。药浴降低 不良事件发生率效果最好的可能性最大。灌肠+常规退热起效时间最短的可能性最大。单纯常规基础治疗联合 药浴或单纯应用灌肠+放血、足浴、灌肠的完全退热时间均少于单纯常规基础治疗。结论:小儿外感发热患者 在常规西医治疗的基础上合理选用中医外治法,能够提高临床有效率,降低不良反应的发生,缩短退热起效时 间、完全退热时间。但由于缺乏不同中医外治法之间的直接比较,上述结论尚待更多高质量研究予以验证。

    Abstract:

    Abstract:Objective:To systematically evaluate the efficacy and safety of Chinese medicine external treatment as an adjunct therapy for pediatric exogenous fever using network meta-analysis(NMA).Methods:A comprehensive search was conducted in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure(CNKI), Wanfang Database, VIP, and China Biomedical Literature Database for randomized controlled trials (RCTs) on Chinese medicine external treatment for pediatric exogenous fever from January 2010 to June 2023. Two researchers independently screened the literature,extracted data,and assessed the risk of bias in the included studies according to predefined criteria. NMA was performed using R-4.3.1 software. Results: A total of 30 RCTs involving 5 888 participants and 19 different interventions were included.The NMA results showed that,in terms of clinical efficacy, compared to conventional basic treatment alone,the combination of conventional basic treatment with Chinese medicine external treatments such as enema, application therapy, bloodletting, medicinal bath, and massage, or the single use of enema+bloodletting, bloodletting+massage, medicinal bath+massage, scraping, enema, medicinal bath, massage, bloodletting + foot bath, medicinal bath + acupuncture and moxibustion, foot bath, bloodletting, and application therapy, were all more effective than conventional basic treatment alone. Medicinal bath had the highest probability of reducing the incidence of adverse events. Enema combined with conventional antipyretic treatment had the shortest time to onset of fever reduction. The complete fever reduction time was shorter with the combination of conventional basic treatment and medicinal bath,or with the use of enema+bloodletting,foot bath,and enema alone, compared to conventional basic treatment alone.Conclusion:The rational use of Chinese medicine external treatment in addition to conventional western medicine can improve clinical efficacy,reduce the adverse reactions,and shorten the time to onset and complete fever reduction in pediatric patients with exogenous fever.However,due to the lack of direct comparisons among different Chinese medicine external treatments, these conclusions need to be validated by more high-quality studies.

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林晓燕,于丽媛,庄杰钦,蔡海荣,冯宇超,曾靖,赵帅.中医外治法辅助治疗小儿外感发热有效性和安全性的网状Meta 分析[J].新中医,2025,57(18):174-183

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