基于数据挖掘分析中药外治骨质增生症用药规律
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R274.9

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黄枫全国名老中医专家传承工作室项目(国中医人教函〔2022〕75号);广州中医药大学“双一流”与高水平大学学科后备人才培育项目(广中医校办〔2022〕90号)


Analysis of Medication Rules of Topical Chinese Herbal Medicine for Hyperosteogeny Based on Data Mining
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    摘要:

    目的:基于数据挖掘技术分析中药外治骨质增生症的用药规律。方法:收集中国知网(CNKI)、 中国学术期刊数据库、中文科技期刊数据库(VIP) 中有关中药外治骨质增生症的方剂。通过R语言对高频药 物、剂型分布、药物功效及性味归经进行统计,挖掘药物关联规则,并采用层次聚类分析探索核心药物组合。 结果:共纳入98首方剂,其中中药外治剂型以水剂为主,熏洗占比最高。高频药物包括红花、威灵仙、透骨 草等,功效集中于活血化瘀、祛风湿及解表。药性以温性为主,药味以苦、辛居多,归经多属肝、脾、胃、肾 经。关联规则分析显示乳香-没药、川乌-草乌为关键药对,角药组合红花-草乌-桃仁、红花-乳香-桃仁相关 性显著。聚类分析将高频药物分为6类,涵盖祛邪、扶正及攻逐顽疾等组方策略。结论:中药外治骨质增生症 以活血行气、祛风除湿、补益肝肾药为主,红花、桃仁、乳香、没药、草乌、川乌等核心药物应用广泛,特别 是乳香与没药的配伍,在解毒消肿、止痛方面效果突出。

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    Abstract: Objective: To analyze the medication rules of topical Chinese herbal medicine for hyperosteogeny using data mining techniques. Methods: Prescriptions for topical Chinese herbal medicine in the treatment of hyperosteogeny were collected from China National Knowledge Infrastructure (CNKI), China Science Periodical Database(CSPD),and China Science and Technology Journal Database(VIP). R language was employed to analyze high-frequency herbs,dosage form distribution,herbal efficacy,properties,flavor,and meridian tropism,to mine the association rules of herbal medicine, and to perform hierarchical cluster analysis for identifying core herbal combinations. Results: A total of 98 prescriptions were included, among which the aqueous preparations were the primary dosage form of topical Chinese herbal medicine,with fumigation-washing preparations accounting for the most. High-frequency herbs included Carthami Flos, Clematidis Radix et Rhizoma, and Speranskiae Tuberculatae Herba, etc., whose primary efficacies were activating blood and removing stasis, expelling wind and eliminating dampness, and releasing the exterior,medicinal properties were predominantly warm,flavors were mainly bitter and pungent and meridian tropisms targeted the liver, spleen, stomach, and kidney meridians. Association rule analysis revealed Olibanum-Myrrha and Aconiti Radix-Aconiti Kusnezoffii Radix as key couplet medicinals. Significant triplet medicinals included Carthami Flos-Aconiti Kusnezoffii Radix-Persicae Semen and Carthami Flos-Olibanum-Persicae Semen. Cluster analysis categorized high-frequency herbs into six groups, reflecting the formulation strategies of eliminating pathogens, reinforcing healthy qi, and combating refractory conditions. Conclusion: Topical Chinese herbal medicine for hyperosteogeny emphasizes core principles of activating blood and promoting qi circulation,expelling wind and eliminating dampness, and tonifying the liver and kidney. Core herbs such as Carthami Flos, Persicae Semen, Olibanum,Myrrha,Aconiti Kusnezoffii Radix,and Aconiti Radix are widely used. The combination of Olibanum and Myrrha demonstrates particularly notable efficacy in detoxifying,reducing swelling,and alleviating pain.

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付阳波,董航,姜自伟.基于数据挖掘分析中药外治骨质增生症用药规律[J].新中医,2025,57(19):1-6

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  • 在线发布日期: 2025-10-20
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