基于数据挖掘分析沈淋源治疗非特异性腰痛用药规律
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R274.9;R249

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2022年广东省科技创新战略专项项目(STKJ202209074)


Data Mining-Based Analysis of SHEN Linyuan's Medication Rules for Non-Specific Low Back Pain
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    摘要:

    目的:基于数据挖掘方法系统分析沈淋源教授治疗非特异性腰痛(NLBP) 的用药规律。方法:运 用古今医案云平台(V2.3.9),通过对沈淋源教授治疗445例NLBP患者的门诊中药处方进行频次统计、关联规 则分析、聚类分析及复杂网络分析,揭示其核心用药特征。结果:共纳入127 味中药,频次>100 次的有 21 味;高频药物以陈皮、牡丹皮、延胡索、防己、桑枝为主,药性以温、平、微寒为主,药味以苦、辛、甘 为主,归经侧重肝、脾、肺、肾经。核心药对为牡丹皮-延胡索、防己-延胡索、防己-牡丹皮、桑枝-延胡索、 桑枝-牡丹皮,聚类分析得到3组高频药物核心聚类组合。通过复杂网络分析得出核心处方为延胡索、牡丹皮、 陈皮、防己、桑枝、厚朴、络石藤、地龙、茵陈、赤芍、秦艽、怀牛膝、川芎、(甘草)。结论:沈淋源教授治 疗NLBP以活血理气、祛湿通络、补益肝肾为核心治法,以牡丹皮-延胡索为核心药对,形成了“寒热并用、 攻补兼施”的配伍原则,同时强调“三因制宜”,高频使用茵陈、海桐皮等岭南特色药,精准针对湿热瘀阻的 地域病机,并以陈皮调摄脾胃。

    Abstract:

    Abstract:Objective:To systematically analyze the medication rules of Professor SHEN Linyuan in treating nonspecific low back pain(NLBP)using data mining. Methods:Based on the Ancient and Morden Medical Case Cloud Platform(V2.3.9), frequency statistics, association rules analysis, cluster analysis, and complex network analysis were applied to 445 outpatient Chinese herbal prescriptions for NLBP patients treated by Professor SHEN. The core characteristics of medication were uncovered through these methods. Results: A total of 127 Chinese herbs were included, with 21 herbs having a frequency over 100. High-frequency herbs were dominated by Citri Reticulatae Pericarpium, Moutan Cortex, Corydalis Rhizoma, Stephaniae Tetrandrae Radix, and Mori Ramulus. The herbal natures were mainly warm, neutral, and slightly cold; flavors focused on bitter, acrid, and sweet; and channel entries were mainly the liver,spleen,lung,and kidney channels. Core herbal pairs included Moutan Cortex-Corydalis Rhizoma, Stephaniae Tetrandrae Radix-Corydalis Rhizoma, Stephaniae Tetrandrae Radix-Moutan Cortex, Mori Ramulus-Corydalis Rhizoma,and Mori Ramulus-Moutan Cortex. Cluster analysis identified three core herbal clusters. Complex network analysis revealed the core prescriptions: Corydalis Rhizoma, Moutan Cortex, Citri Reticulatae Pericarpium, Stephaniae Tetrandrae Radix, Mori Ramulus, Magnoliae Officinalis Cortex, Trachelosperi Caulis et Folium, Pheretima, Artemisiae Scopariae Herba, Paeoniae Radix Rubra, Gentianae Macrophyllae Radix, Achyranthis Bidentatae Radix, Chuanxiong Rhizoma, and(Glycyrrhizae Radix et Rhizoma). Conclusion: The medication rules of Professor SHEN Linyuan in the treatment of NLBP take invigorating blood and regulating qi, removing dampness and unblocking collaterals, and supplementing and boosting the liver and kidney as the core therapeutic methods,take Moutan Cortex-Corydalis Rhizoma as the core herbal pair,form the compatibility principle of "using cold and heat together, and combining attacking with supplementing", and emphasize "treatment in accordance with three categories of etiological factors". He frequently uses Lingnan characteristic herbs such as Artemisiae Scopariae Herba,and Aralia Chinensis L,precisely targeting the regional pathogenesis of damp-heat and stasis obstruction,and frequently uses Citri Reticulatae Pericarpium to regulate the spleen and stomach.

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游振宇,姚莹华,沈淋源.基于数据挖掘分析沈淋源治疗非特异性腰痛用药规律[J].新中医,2025,57(19):7-12

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  • 在线发布日期: 2025-10-20
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