基于数据挖掘分析张晋峰治疗多囊卵巢综合征用药规律及学术思想
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R249;R271.9

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第二批山西省老中药专家学术经验继承工作室(晋卫中医药函(2022) 36号);山西省卫生健康委科研项目(2024115);山西省卫生健康委员会重点实验室建设计划项目(2020SYS06);山西省中医药管理局传承创新项目(2023ZYYC014)


Data Mining Analysis of Medication Patterns and Academic Thoughts in ZHANG Jin⁃ feng's Treatment of Polycystic Ovary Syndrome
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    摘要:

    目的:基于数据挖掘分析张晋峰治疗多囊卵巢综合征(PCOS) 用药规律及学术思想,指导临床用 药。方法:通过山西省中医院卫宁健康门诊医生工作站系统收集2021年12月至2024年12月张晋峰门诊确诊的 PCOS病例处方,建立Excel数据库。对处方中药物进行频次、性味、归经、功效统计,采用IBM SPSS Modeler 软件Apriori模块进行核心药物关联规则、药对、角药组合分析,利用OriginPro软件进行聚类分析。结果:筛 选得到110首处方,涉及中药157味,使用频次1 518次。药味以苦、甘、辛为主,药性多温、寒、平,主归 肝、脾、肺、肾经;功效以补虚、活血化瘀、清热药占主导。高频药物关联规则分析得到26对药对及30对角 药。聚类分析得到5个药物组合,分别体现了祛湿化痰、行气活血;补气升阳、祛风止痛;调经止痛、清热凉 血;化瘀止血、平肝安神;补气补血、固精止带的治法。结论:张晋峰治疗PCOS注重整体辨证施治,以补肾 为本,祛痰、湿、瘀为标;多选用苦甘健脾之药;祛湿化痰药常与行气活血药并用;基于患者偏重,多数药使 用剂量偏大。

    Abstract:

    Abstract: Objective: To summarize the medication patterns and academic thoughts of ZHANG Jinfeng in treating polycystic ovary syndrome(PCOS) based on data mining, thus providing guidance for clinical practice. Methods:PCOS prescriptions from ZHANG Jinfeng's outpatient clinic between December 2021 and December 2024 were collected through the Weining Health Outpatient Doctor Workstation System of Shanxi Traditional Chinese Medicine Hospital's electronic medical record system and compiled into an Excel database. Statistical analysis was performed on herbfrequency,properties,channeltropism,andtherapeuticeffects.Coreherbassociations,herbpairs,andtriple-herb combinations were analyzed using the Apriori algorithm in IBM SPSS Modeler,while cluster analysis was conducted with OriginPro software. Results: A total of 110 prescriptions involving 157 Chinese herbs with 1 518 applications were analyzed. Predominant herb flavors were bitter, sweet, and acrid; natures were mainly warm, cold, and neutral; primary channel distributions were liver,spleen,lung,and kidney meridians. Therapeutic effects were dominated by tonifying deficiency,activating blood circulation to resolve stasis,and clearing heat. High-frequency herb association analysis identified 26 herb pairs and 30 triple-herb combinations. Cluster analysis revealed five herb clusters reflecting distinct treatment principles:eliminating dampness and resolving phlegm with qi-moving and blood-activating herbs; tonifying qi and raising yang with wind-dispersing and pain-relieving herbs;regulating menstruation and relieving pain with heat-clearing and blood-cooling herbs;resolving stasis to stop bleeding with liver-calming and mind-tranquilizing herbs; supplementing qi and blood with emission-arresting and leukorrhea-reducing herbs. Conclusion: ZHANG Jinfeng's treatment of PCOS emphasizes holistic syndrome differentiation, focusing on kidney tonification as the root approach while addressing phlegm,dampness,and stasis as secondary manifestations. Bitter-sweet spleen-strengthening herbs are preferentially selected, with dampness-eliminating and phlegm-resolving herbs often combined with qimoving and blood-activating herbs. Dosages are generally substantial due to patients' heavy weight.

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宋美卿,张晋峰,张丽,牛艳艳,杨钤,亢馨婧,邢建月.基于数据挖掘分析张晋峰治疗多囊卵巢综合征用药规律及学术思想[J].新中医,2025,57(19):18-25

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