Abstract： Objective： To observe the clinical efficacy of modified Buxue Runzao Prescription combined with medium-frequency gastrointestinal therapeutic device in treating neurogenic bowel dysfunction with blood deficiency and intestinal dryness syndrome after spinal cord injury. Methods： A total of 80 patients with neurogenic bowel dysfunction with blood deficiency and intestinal dryness syndrome after spinal cord injury treated at Zhengzhou Central Hospital Affiliated to Zhengzhou University from June 2021 to June 2024 were selected and divided into a control group and an observation group， with 40 cases in each group， using a random number table method. Both groups received conventional treatment. The control group was treated with a medium-frequency gastrointestinal therapeutic device， while the observation group was additionally treated with modified Buxue Runzao Prescription on the basis of the control group. Clinical efficacy was compared between the two groups，as well as changes in Wexner Constipation Score（WSC）， Neurogenic Bowel Dysfunction Score（NBD）， and neurofunctional indicators [brain-derived neurotrophic factor （BDNF）， and neuron - specific enolase（NSE）] before and after treatment. Results： After treatment， the total effective rate in the observation group was 94.59%（35/37），higher than that in the control group at 78.38%（29/37） （P＜0.05）. The WSC and NBD decreased in both groups compared to before treatment（P＜0.05），with the observation group achieving lower scores than the control group（P＜0.05）. The BDNF levels decreased in both groups compared to before treatment（P＜0.05），with the observation group achieving lower levels than the control group（P＜0.05）. The NSE levels increased in both groups compared to before treatment（P＜0.05）， with the observation group achieving higher levels than the control group（P＜0.05）. Conclusion： Modified Buxue Runzao Prescription combined with medium-frequency gastrointestinal therapeutic device in treating neurogenic bowel dysfunction with blood deficiency and intestinal dryness syndrome after spinal cord injury can further enhance clinical efficacy， relieve constipation symptoms，and improve intestinal and neurofunctional functions.