Abstract：Objective：To systematically elucidate the multi-target mechanism of modified Poge Jiuxin Decoction in treating sepsis using network pharmacology and systems biology. Methods：Active components and their targets were screened via Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）and Herb databases. Sepsis-related targets were retrieved from OMIM and GeneCards. Common targets were identified through venn analysis. Protein-protein interaction（PPI）networks were constructed using Cytoscape，with core targets selected. Gene Ontology （GO） functional annotation and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment were performed via Metascape. R language visualized the network pharmacology profiles. Results： We identified 34 active components and 195 therapeutic targets for the Decoction， and 1 722 sepsis-related targets， yielding 102 drug-disease over lapping targets. PPI analysis revealed core targets primarily regulating inflammatory cascades and apoptosis. GO analysis showed molecular function（MF）enriched in protein kinase binding，transcription factor binding；cellular component（CC）focused on membrane rafts，external plasma membrane；biological process （BP）involved in response to bacterial molecules and cytokine stimulation. KEGG enrichment indicated key pathways including lipid and atherosclerotic metabolic pathways，NF-κB signaling pathways，and phosphatidylinositol 3-kinase/ protein kinase B（PI3K / AKT） apoptosis pathways， and had significant anti-inflammatory， antioxidant stress and apoptotic regulatory characteristics. Molecular connection verification shows that key components such as quercetin，β- sitosterol，kaempferol，naringenin and ginsenoside Rh2 can synergistically regulate core components such as estrogen receptor 1（ESR1），B-cell lymphoma 2（BCL2），caspase 3（CASP3），peroxisome proliferator-activated receptor γ （PPARG）， and tumor necrosis factor （TNF） through multiple targets expression of target genes. Conclusion： Modified Poge Jiuxin Decoction acts on core targets such as ESR1， BCL2， CASP3， PPARG and TNF through core components like quercetin， β - sitosterol， kaempferol， naringenin and ginsenoside Rh2， and regulates excessive inflammatory responses and improves organ dysfunction through key signaling pathways such as NF-κB/PI3K-AKT.