Abstract：Objective：To observe the clinical effect of Guanxinning Tablets combined with western medicine on stable angina pectoris complicated with mild hypertension of heart blood stasis type and its effects on hemorheology and vascular endothelial function. Methods： A total of 98 cases of patients with stable angina pectoris and mild hypertension of heart blood stasis type，who were treated at Changxing Hospital of Traditional Chinese Medicine from January to December 2022，were selected and divided into the control group（49 cases）and the trial group（49 cases） according to the random number table method. The control group was treated with western medicine，and the trial group was treated with Guanxinning Tablets in addition to the treatment given to the control group. Both groups were treated for one month. Clinical effects，traditional Chinese medicine syndrome scores，duration of angina pectoris，frequency of angina attacks， blood pressure， heart function indexes， hemorheology indexes， and vascular endothelial function indexes were compared between the two groups. The incidence of adverse reactions was recorded. Results：After one month of treatment， the total effective rate was 95.92%（47/49）in the trial group， which was higher than that of 79.59%（39 / 49） in the control group（P＜0.05）. Traditional Chinese medicine syndrome scores for chest pain， palpitations， insomnia， fatigue， and dizziness in the two groups were decreased when compared with those before treatment（P＜0.05）， with the trial group showing lower scores than the control group（P＜0.05）. The duration of angina pectoris in the two groups was shortened when compared with that before treatment（P＜0.05）， with the trial group showing a shorter duration than the control group（P＜0.05）. The frequency of angina attacks， diastolic blood pressure，and systolic blood pressure in the two groups were reduced when compared with those before treatment（P＜ 0.05）， with the trial group showing lower values than the control group（P＜0.05）. Left ventricular ejection fraction （LVEF），cardiac output（CO），and cardiac index（CI）in the two groups were increased when compared with those before treatment（P＜0.05），with the trial group showing higher values than the control group（P＜0.05）. Whole blood hematocrit，whole blood high shear viscosity，and plasma viscosity in the two groups were reduced when compared with those before treatment（P＜0.05）， with the trial group showing lower values than the control group（P＜0.05）. The levels of Visfatin， Leptin， Endothelin-1（ET-1）， and Angiotensin Ⅱ（Ang Ⅱ）in serum in the two groups were decreased when compared with those before treatment（P＜0.05）， with the trial group showing lower levels than the control group（P＜0.05）. The levels of adiponectin（APN）in serum in the two groups were increased when compared with those before treatment（P＜0.05），with the trial group showing a higher level than the control group（P＜0.05）. During the treatment period， no significant gastrointestinal reactions or liver and kidney function abnormalities were observed in either group. Conclusion： Guanxinning Tablets combined with western medicine can improve blood pressure，heart function，hemorheology，and vascular endothelial function in patients with stable angina pectoris and mild hypertension of heart blood stasis type， thereby controlling clinical symptoms and enhancing curative effect with good safety.