Abstract：Objective：To observe the effect of Huoxin Pills（Concentrated Pills）on cardiac function and serum free fatty acid（FFA）levels in the treatment of chronic heart failure（CHF）. Methods： A total of 116 CHF patients treated at Guanghan People's Hospital，from July 2022 to June 2024 were selected and divided into the control group and the trial group using the random number table method， with 58 cases in each group. During treatment， 6 cases dropped out in the trial group. Ultimately，110 cases were included：58 in the control group and 52 in the trial group. The control group received conventional western medicine treatment， while the trial group received Huoxin Pills （Concentrated Pills）in addition to the conventional treatment. The treatment course for both groups was three months. Levels of serum FFA and N-terminal pro-B-type natriuretic peptide（NT-proBNP）， New York Heart Association （NYHA）functional class，6-minute walk test（6MWT）distance，Minnesota Living with Heart Failure Questionnaire （MLHFQ） scores， left ventricular ejection fraction（LVEF）， left ventricular fractional shortening（LVFS）， left ventricular end-systolic dimension（LVESD）before and after treatment，and medication safety were observed in both groups. Results：After treatment，serum FFA levels decreased significantly in both groups when compared with those before treatment（P＜0.05），and the FFA level in the trial group was lower than that in the control group（P＜0.05）. Serum NT-proBNP levels decreased significantly in both groups when compared to pre-treatment levels（P＜0.05）， and the NT-proBNP level in the trial group was lower than that in the control group（P＜0.05）. After treatment， the 6MWT distance significantly increased in the trial group when compared to pre-treatment levels and was greater than that in the control group， differences being significant（P＜0.05）； there was no significant difference in the 6MWT distance in the control group before and after treatment（P＞0.05）. After treatment，scores in the physical，emotional， and other domains，as well as the total score of the MLHFQ，decreased significantly in both groups when compared to pre-treatment levels（P＜0.05），and all scores were lower in the trial group than in the control group（P＜0.05）. After treatment，NYHA functional class improved significantly in both groups（P＜0.05），and this improvement was better in the trial group than in the control group（P＜0.05）. After treatment，LVEF and LVFS levels increased significantly in the trial group（P＜0.05）， while LVESD decreased significantly（P＜0.05）. Furthermore， LVEF and LVFS levels were higher in the trial group than in the control group（P＜0.05）， and LVESD was smaller in the trial group（P＜ 0.05）. During treatment， there was no significant difference between the two groups in the readmission rate or the incidence of adverse reactions such as abdominal distension and poor appetite， nausea， and palpitations（P＞0.05）. Conclusion：Huoxin Pills（Concentrated Pills）in the treatment of CHF can reduce serum FFA and NT-proBNP levels， improve exercise tolerance，and enhance cardiac function and quality of life.