Abstract：Objective：To observe the clinical efficacy of Shugan Hewei Prescription combined with Rabeprazole Sodium Enteric-Coated Tablets in the treatment of reflux esophagitis（RE）of liver-stomach disharmony type. Methods： Patients with RE of liver-stomach disharmony type who visited Foshan Hospital of Traditional Chinese Medicine from January to October 2024 were selected. Patients were assigned to three groups using a stratified random sampling method with a 1∶ 1∶ 1 allocation ratio， with 30 cases selected for each group， namely the western medicine group， the Shugan Hewei group， and the combined group. The western medicine group was treated with Rabeprazole Sodium Enteric-Coated Tablets，the Shugan Hewei group was treated with Shugan Hewei Prescription，and the combined group was treated with Shugan Hewei Prescription combined with Rabeprazole Sodium Enteric-Coated Tablets. All three groups were treated for eight weeks. The clinical efficacy，traditional Chinese medicine symptom scores，Gastroesophageal Reflux Disease Questionnaire（GerdQ）scores，and endoscopy scores were compared among the three groups.Record the occurrence of adverse reactions in the three groups. Results： The total effective rate of clinical efficacy was 96.30% （26/27）in the combined group，85.71%（24/28）in the Shugan Hewei group，and 71.42%（20/28）in the western medicine group. The combined group had a significantly higher total effective rate of clinical efficacy than the western medicine group（P＜0.017）. There was no significant difference in the total effective rate of clinical efficacy between the Shugan Hewei group and the western medicine group，or between the Shugan Hewei group and the combined group（P＞ 0.017）. After eight weeks of treatment， the traditional Chinese medicine symptom scores in all three groups were significantly decreased compared with those before treatment（P＜0.05）. The traditional Chinese medicine symptom scores in the combined group were lower than those in the western medicine group and the Shugan Hewei group（P＜ 0.017）. There was no significant difference in traditional Chinese medicine symptom scores between the Shugan Hewei group and the western medicine group（P＞0.017）. The difference in traditional Chinese medicine symptom scores before and after treatment was greater in the combined group and the Shugan Hewei group than in the western medicine group（P＜0.017）. There was no significant difference in the difference of traditional Chinese medicine symptom scores before and after treatment between the combined group and the Shugan Hewei group（P＞0.017）. After eight weeks of treatment，the GerdQ and endoscopy scores in all three groups were significantly decreased compared with those before treatment（P＜0.05）. There was no significant difference in the above two scores among the groups（P＞0.017）. The difference in GerdQ scores before and after treatment was greater in the combined group and the Shugan Hewei group than in the western medicine group（P＜0.017）. There was no significant difference in the difference of GerdQ scores before and after treatment between the combined group and the Shugan Hewei group（P＞0.017）. The difference in endoscopy scores before and after treatment was greater in the combined group than in the western medicine group（P＜ 0.017）. There was no significant difference in the difference of endoscopy scores before and after treatment between the Shugan Hewei group and the combined group or the western medicine group （P＞0.017）. No significant adverse reactions occurred during the treatment period in all three groups. Conclusion：Shugan Hewei Prescription combined with Rabeprazole Sodium Enteric-Coated Tablets can effectively improve the clinical symptoms of patients with RE of liver-stomach disharmony type，promote the repair of esophageal mucosa，and is safe.