Abstract：Objective：To observe the clinical effect of the combination of Zhige Baogan Prescription and Polyene Phosphatidylcholine on alcoholic liver disease（ALD）with internal accumulation of damp-heat syndrome. Methods：A total of 136 ALD patients with internal accumulation of damp-heat syndrome who were admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from November 2023 to November 2024 were included and divided into the control group and the trial group according to the random number table method，with 68 cases in each group. The control group was treated with Polyene Phosphatidylcholine Capsules and the trial group was additionally treated with Zhige Baogan Prescription based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects， liver function indexes [alkaline phosphatase（ALP）， γ -glutamyl-transpeptidase（GGT）and total bilirubin（TBil）]，liver fibrosis indexes [hyaluronic acid（HA），tissue inhibitors of metalloproteinase-1（TIMP-1）and procollagen（PCⅢ）] and incidence of adverse reactions were compared between the two groups. Results：After 12 weeks of treatment，the total clinical effective rate was 91.93%（57/62）in the trial group，higher than that of 77.78%（49/63） in the control group， the difference being significant（P＜0.05）. The levels of serum ALP， GGT， and TBil in both groups were decreased when compared with those before treatment，and the above three levels in the trial group were lower than those in the control group，differences being significant（P＜0.05）. The levels of serum HA，TIMP-1，and PCⅢ in both groups of alcoholic hepatitis patients were decreased when compared with those before treatment，and the above three levels in the trial group were lower than those in the control group，differences being significant（P＜0.05）. The incidence of adverse reactions was 9.68%（6/62）in the trial group and 4.76%（3/63）in the control group，there being no significance in the difference（P＞0.05）. Conclusion： The combination of Zhige Baogan Prescription and Polyene Phosphatidylcholine can enhance the curative effect on ALD with internal accumulation of damp-heat syndrome， promote the recovery of liver function and reduce liver fibrosis with great safety.