Abstract：Objective：To observe the clinical effect of the combination of Chinese medicine hot compress and red light irradiation on diabetic peripheral neuropathy（DPN） of qi-yin deficiency complicated with blood stasis type. Methods： A total of 80 DPN patients of qi-yin deficiency complicated with blood stasis type who were treated in Pinghu Hospital of Chinese Medicine from January 2023 to June 2024 were selected and divided into the study group and the control group according to the random number table method， with 40 cases in each group. The control group was treated with Epalrestat orally，and the study group was treated with Chinese medicine hot compress combined with red light irradiation. The traditional Chinese medicine syndrome scores，scores of Toronto Clinical Scoring System（TCSS）， levels of blood glucose indexes [fasting blood glucose（FBG）and 2 h postprandial blood glucose（P2hBG）]， nerve conduction velocity [motor nerve conduction velocity（MCV）and sensory nerve conduction velocity（SCV）of common peroneal nerve and tibial nerve]， vibration perception threshold（VPT）， hemorheology indexes， clinical effects and safety were compared between the two groups. Results：After treatment，the total effective rate was 95.00%（38/40）in the study group and 77.50%（31/40）in the control group，the difference being significant（P＜0.05）. After treatment， the traditional Chinese medicine syndrome scores and TCSS scores in the two groups were reduced when compared with those before treatment（P＜0.05），and the above scores in the study group were lower than those in the control group （P＜0.05）. After treatment，the levels of FBG and P2hBG in the two groups were decreased when compared with those before treatment（P＜0.05），and the above two levels in the study group were lower than those in the control group（P＜ 0.05）. After treatment，MCV and SCV of common peroneal nerve and tibial nerve in the two groups were elevated when compared with those before treatment（P＜0.05），and the levels of the above indexes in the study group were higher than those in the control group（P＜0.05）. After treatment，the VPT of left and right feet in the two groups were downregulated when compared with those before treatment（P＜0.05），and the VPT of left and right feet in the study group was lower than that in the control group（P＜0.05）. After treatment，the hematocrit，platelet adhesion rate and plasma specific viscosity in the two groups were decreased when compared with those before treatment（P＜0.05）， and the levels of the above three indexes in the study group were lower than those in the control group（P＜0.05）. During the treatment，there were no serious adverse reactions in both groups. Conclusion：The combination of Chinese medicine hot compress and red light irradiation can effectively alleviate related symptoms of DPN of qi-yin deficiency complicated with blood stasis type，reduce the blood glucose levels，improve the nerve conduction velocity，and down-regulate the blood viscosity and VPT with good safety.