Abstract：Objective：To observe the clinical effect of the combination of Bushen Huoxue Qingre Prescription and integrated western medicine therapy on phase 4 chronic kidney disease（CKD）with kidney deficiency and blood stasis complicated with damp-heat syndrome. Methods：A total of 102 patients with phase 4 CKD admitted to Anji County Hospital of Chinese Medicine from January 2023 to July 2024 were included and divided into the control group and the observation group according to the random number table method，with 51 cases in each group. During the trial，2 cases were excluded from both groups，and finally 49 cases in each group were included in the analysis. The control group was treated with conventional integrated western medicine therapy，and the observation group was additionally treated with Bushen Huoxue Qingre Prescription in addition to the conventional western medicine. After one month of treatment，the clinical efficacy， traditional Chinese medicine syndrome scores， kidney function indexes [serum creatinine（SCr）， blood urea nitrogen（BUN）and estimated glomerular filtration rate（eGFR）]，serum potassium，hemoglobin（Hb），urine protein indexes [24-hour urine total protein （24 hUTP）， urinary α1-microglobulin （Uα1-MG） and urinary β2- microglobulin（Uβ2 -MG）] and the incidence of adverse reactions were evaluated in the two groups. Results： After treatment，the total effective rate was 89.80%（44/49）in the observation group，higher than that of 73.47%（36/49）in the control group，and the difference between the two groups being significant（P＜0.05）. After treatment，the scores of main symptoms and secondary symptoms and the total scores in the two groups were decreased when compared with those before treatment（P ＜ 0.05）， and each score in the observation group was lower than that in the control group（P ＜ 0.05）. After treatment， the levels of serum BUN and SCr in the two groups were down-regulated when compared with those before treatment（P＜0.05）， and the levels of eGFR were increased when compared with those before treatment（P＜0.05）；the levels of BUN and SCr in the observation group were lower than those in the control group（P＜0.05），and the level of eGFR in the observation group was higher than that in the control group（P＜0.05）. After treatment，the levels of Hb in the two groups were up-regulated when compared with those before treatment，and the level of Hb in the observation group was higher than that in the control group， differences being significant（P＜ 0.05）. After treatment，the levels of 24 hUTP，Uα1-MG and Uβ2-MG in the two groups were reduced when compared with those before treatment（P＜0.05），and the above three levels in the observation group were lower than those in the control group（P＜0.05）. There was no significant difference being found in the comparison of level of serum potassium between the two groups before and after treatment（P＞0.05）. During the treatment，the incidence of adverse reactions in the control group was 20.40%（10/49），higher than that of 6.12%（3/49）in the observation group，the difference being significant（P＜0.05）. Conclusion： The combination of Bushen Huoxue Qingre Prescription and conventional integrated western medicine therapy has a significant curative effect on patients with phase 4 CKD with kidney deficiency and blood stasis complicated with damp-heat syndrome， this combined therapy can effectively reduce the traditional Chinese medicine syndromes of patients，improve the kidney function and anemia，and reduce the level of urine protein and the incidence of adverse reactions.