Abstract：Objective：To observe the clinical efficacy of tendon-regulating and meridian-dredging manipulation in the treatment of lumbar disc herniation（LDH）and its effect on inflammatory factor levels. Methods： A total of 150 LDH patients admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from December 2022 to December 2023 were divided into the western medicine group and the manipulation group using the random number table method， with 75 cases in each group. The western medicine group received oral Celecoxib， while the manipulation group underwent tendon-regulating and meridian-dredging manipulation. The changes in pain severity [Visual Analogue Scale （VAS） score]， lumbar function [Japanese Orthopaedic Association （JOA） score]， levels of inflammatory factors [interleukin-1（IL-1）， interleukin-6（IL-6）]， and clinical efficacy were compared between the two groups. Results：After treatment，the total effective rate was 90.67%（68/75）in the manipulation group and 65.33%（49/75） in the western medicine group，showing a statistically significant difference（P＜0.05）. After treatment，both groups showed reduced VAS scores compared with those before treatment（P＜0.05），and the manipulation group had lower VAS scores than the western medicine group（P＜0.05）； both groups showed increased JOA scores compared with those before treatment（P＜0.05），and the manipulation group had higher JOA scores than the western medicine group （P＜0.05）；serum levels of IL-1 and IL-6 decreased in both groups compared with those before treatment（P＜0.05）， with the two indicators being significantly lower in the manipulation group than those in the western medicine group（P＜ 0.05）. Conclusion：Tendon-regulating and meridian-dredging manipulation effectively inhibits systemic inflammatory responses，alleviates pain，and improves lumbar function in LDH patients，thereby improving clinical efficacy.