Abstract： Objective： To analyze the action mechanism of Guanxinning in treating hyperhomocysteinemia （HHcy）based on network pharmacology. Methods：The active components and targets of Salviae Miltiorrhizae Radix et Rhizoma and Chuanxiong Rhizoma were screened by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）and A Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine（BATMAN 2.0）. Disease targets were obtained from the Genecards and OMIM databases； a Venn diagram was used to identify common targets. A medicine-component-target-disease target interaction network was constructed and visualized by Cytoscape 3.8.2；Gene Ontology（GO）and Kyoto Encyclopedia of Genes and Genomes （KEGG）enrichment analyses were performed. Results：A total of 69 active components of Chuanxiong Rhizoma and 124 active components of Salviae Miltiorrhizae Radix et Rhizoma were identified，with a combined total of 871 targets； there were 377 HHcy targets. Quercetin，oleic acid，ursolic acid，cryptotanshinone，and L-glutamine were identified as the main components of Guanxinning in treating HHcy. Key targets included protein kinase B（AKT1）， tumor necrosis factor（TNF），interleukin-6（IL-6），insulin-induced gene（INS），caspase-3（CASP3），interleukin-1β （IL-1β），transforming growth factor-β1（TGF-β1），and matrix metalloproteinase-9（MMP9）. GO enrichment analysis indicated that the targets of Guanxinning in treating HHcy were mainly involved in biological processes（BP）such as chemical stress，oxidative stress，nutrient levels，reactive oxygen species，and lipopolysaccharide response；cellular components（CC）included membrane rafts， membrane microdomains， membrane regions， platelet granules， and endoplasmic reticulum lumen； molecular functions（MF）included signal receptor activator activity， receptor ligand activity， cytokine activity， cytokine receptor binding， and protease binding. KEGG pathway enrichment analysis suggested that Guanxinning mainly involves lipid and atherosclerosis pathways in treating HHcy. Conclusion： Guanxinning treats HHcy through multiple targets and pathways. Quercetin， oleic acid， ursolic acid， cryptotanshinone， and L-glutamine are important components， and AKT1， TNF， IL-6， INS， CASP3， IL-1β， TGF-β1，and MMP9 are potential key targets. This study provides a theoretical basis for the mechanism of Guanxinning in treating HHcy.