Abstract：LI Yao posits that gastroesophageal reflux disease（GERD）falls within the scope of traditional Chinese medicine syndromes such as acid regurgitation and esophageal heat. The pathogenesis is closely related to the liver， spleen，and kidney. The fundamental pathogenesis of liver cold syndrome involves water-cold，earth-dampness，and wood-stagnation. For mild liver cold syndrome， LI Yao's experienced prescription of Jianglian Yisuan Decoction is modified to warm the liver，dispel cold，harmonize the stomach，and direct rebellious qi downward. In severe cases， Wuzhuyu Sini Decoction is employed to supplement fire，dry earth，and free wood stagnation. Flexible prescription has demonstrated significant therapeutic efficacy.