Abstract： Objective： To analyze the medication patterns of Chinese medicine for hypoxic pulmonary hypertension（HPH）using data mining and to identify core Chinese medicine combinations. Additionally，to explore the mechanisms of action using network pharmacology and molecular docking techniques. Methods：Literature on Chinese medicine treatment of HPH published in the China Biology Medicine disc （CBM）， China National Knowledge Infrastructure（CNKI），Wanfang Data，and VIP Journal Database from the inception of these databases to February 29， 2024， was screened. The Traditional Chinese Medicine Inheritance Assistant Platform（V2.5）software was used to analyze medication patterns and identify core Chinese medicine combinations. The TCMSP database was used to screen active components of core Chinese medicine and their targets. Targets for HPH were obtained from GeneCards，OMIM， and PubChem databases. Cytoscape software and the STRING database were used to construct core networks and proteinprotein interaction networks. Gene Ontology（GO）and Kyoto Encyclopedia of Genes and Genomes（KEGG）enrichment analyses were conducted. Finally，molecular docking techniques were used to verify the binding affinity between active components of core Chinese medicine and core targets. Results：A total of 153 prescriptions were included，covering 131 Chinese medicine herbs. The core Chinese medicine combination identified was "Salviae Miltiorrhizae Radix et Rhizoma， Astragali Radix， and Chuanxiong Rhizoma". There were 92 active components identified， with the main active components being luteolin，tanshinone ⅡA，quercetin，kaempferol，and isorhamnetin. There were 190 common targets between the core Chinese medicine and HPH，with key targets being TP53，STAT3，AKT1，and HSP90AA1. The GO enrichment analysis suggested that the core Chinese medicine combination acts through molecular functions such as DNA-binding transcription factor binding in membrane rafts and biological processes such as oxidative stress. The KEGG pathway enrichment analysis indicated that the main mechanisms of action include the PI3K-Akt，MAPK， TNF， and IL-17 signaling pathways. Molecular docking results showed strong binding activity between key active components of core Chinese medicine and core targets. Conclusion： The core Chinese medicine combination "Chuanxiong Rhizoma，Astragali Radix，and Salviae Miltiorrhizae Radix et Rhizoma" in Chinese medicine treatment of HPH acts through multiple components，targets，and pathways to intervene in HPH.