Analysis of Medication Rules of LIU's Traditional Chinese Medicine Pediatrics in Jinan in Treating Children with Functional Abdominal Pain Based on Data Mining Technology
Abstract:Objective:To analyze the medication rules of LIU's traditional Chinese medicine(TCM)pediatrics in Jinan in treating children with functional abdominal pain(FAP)based on data mining technology. Methods:The case data of FAP children diagnosed and treated by the inheritors of LIU's TCM pediatrics in the Outpatient Department of Pediatrics of Jinan Municipal Hospital of Traditional Chinese Medicine from June 1,2021 to November 30,2022 were collected, and the medication prescriptions were extracted. A database was established using Microsoft Office Excel 2016 software. The Apriori algorithm and agnes function in R language were used to analyze the medication rules of LIU's TCM pediatrics in treating children with FAP. Results: A total of 326 prescriptions were included, involving 175 kinds of Chinese herbs,with a total frequency of 4 633 times. The Chinese herbs with a usage frequency of ≥30% in descending order were Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Citri Reticulatae Pericarpium, Corydalis Rhizoma, Aucklandiae Radix, Amomi Fructus, Massa Medicata Fermentata, Pinelliae Rhizoma, Poria, etc. The properties of these Chinese herbs are mainly warm, followed by cold and neutral. The flavors are mainly pungent and bitter,followed by sweet. The meridian entries are mainly the spleen and stomach meridians,followed by the lung and liver meridians. Cluster analysis obtained five core drug combinations. The first group includes Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Corydalis Rhizoma, Aucklandiae Radix, Citri Reticulatae Pericarpium, Crataegi Fructus, Aurantii Fructus, Amomi Fructus, Cyperi Rhizoma, Toosendan Fructus, Amomi Fructus Rotundus,Portulacae Herba,Lonicerae Japonicae Flos,and Galli Gigerii Endothelium Corneum. The second group includes Massa Medicata Fermentata, Hordei Fructus Germinatus, Pinelliae Rhizoma, Raphani Semen, and Bambusae Caulis in Taenias. The third group includes Poria, Atractylodis Macrocephalae Rhizoma, and Dioscoreae Rhizoma. The fourth group includes Magnoliae Officinalis Cortex, Atractylodis Rhizoma, Pogostemonis Herba, Coptidis Rhizoma, Scutellariae Radix, and Coicis Semen. The fifth group includes Forsythiae Fructus, Taraxaci Herba, Bupleuri Radix, Fritillariae Thunbergii Bulbus, Prunellae Spica, and Ostreae Concha. Conclusion: The basic therapeutic principles of LIU's TCM pediatrics in treating children with FAP are regulating the liver and spleen, and regulating qi to alleviate pain. According to the differences in syndrome manifestations,methods such as promoting digestion and resolving stagnation,replenishing qi and strengthening the spleen,clearing heat and resolving dampness, and detoxifying and resolving masses can be used respectively.