基于数据挖掘技术分析济南刘氏中医儿科治疗儿童功能性腹痛用药规律
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R272.6

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2022年济南市卫健委中医药科技计划(2022-中-05);2024扁鹊故里中医药文化研究(济卫中医综合函〔2024〕5号)


Analysis of Medication Rules of LIU's Traditional Chinese Medicine Pediatrics in Jinan in Treating Children with Functional Abdominal Pain Based on Data Mining Technology
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    摘要:

    目的:基于数据挖掘技术分析济南刘氏中医儿科治疗儿童功能性腹痛(FAP) 的用药规律。方法:收集 2021年6月1日—2022年11月30日刘氏中医儿科传承人于济南市中医医院儿科门诊诊治的FAP患儿病例资料, 提取用药处方,建立Microsoft Office Excel 2016数据库,运用R语言中的Apriori算法、agnes函数分析刘氏中医 儿科治疗儿童FAP的用药规律。结果:共纳入处方326个,涉及中药175味,总频次4 633次。使用频率≥30% 的中药由高到低依次为甘草、白芍、陈皮、延胡索、木香、砂仁、神曲、半夏、茯苓等。中药药性以温性为 主,其次是寒性、平性,药味以辛味、苦味为主,其次是甘味,归经以脾经、胃经为主,其次是肺经、肝经。 聚类分析得到5个核心药物组合,第1组为甘草、白芍、延胡索、木香、陈皮、山楂、枳壳、砂仁、香附、川 楝子、豆蔻、马齿苋、金银花、鸡内金;第2组为神曲、麦芽、半夏、莱菔子、竹茹;第3组为茯苓、白术、 山药;第4组为厚朴、苍术、广藿香、黄连、黄芩、薏苡仁;第5组为连翘、蒲公英、柴胡、浙贝母、夏枯草、 牡蛎。结论:刘氏中医儿科治疗儿童FAP以调和肝脾、理气止痛为基本治疗思路,根据证候表现差异,可分别 兼以消食导滞、益气健脾、清热化湿、解毒散结之法。

    Abstract:

    Abstract:Objective:To analyze the medication rules of LIU's traditional Chinese medicine(TCM)pediatrics in Jinan in treating children with functional abdominal pain(FAP)based on data mining technology. Methods:The case data of FAP children diagnosed and treated by the inheritors of LIU's TCM pediatrics in the Outpatient Department of Pediatrics of Jinan Municipal Hospital of Traditional Chinese Medicine from June 1,2021 to November 30,2022 were collected, and the medication prescriptions were extracted. A database was established using Microsoft Office Excel 2016 software. The Apriori algorithm and agnes function in R language were used to analyze the medication rules of LIU's TCM pediatrics in treating children with FAP. Results: A total of 326 prescriptions were included, involving 175 kinds of Chinese herbs,with a total frequency of 4 633 times. The Chinese herbs with a usage frequency of ≥30% in descending order were Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Citri Reticulatae Pericarpium, Corydalis Rhizoma, Aucklandiae Radix, Amomi Fructus, Massa Medicata Fermentata, Pinelliae Rhizoma, Poria, etc. The properties of these Chinese herbs are mainly warm, followed by cold and neutral. The flavors are mainly pungent and bitter,followed by sweet. The meridian entries are mainly the spleen and stomach meridians,followed by the lung and liver meridians. Cluster analysis obtained five core drug combinations. The first group includes Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Corydalis Rhizoma, Aucklandiae Radix, Citri Reticulatae Pericarpium, Crataegi Fructus, Aurantii Fructus, Amomi Fructus, Cyperi Rhizoma, Toosendan Fructus, Amomi Fructus Rotundus,Portulacae Herba,Lonicerae Japonicae Flos,and Galli Gigerii Endothelium Corneum. The second group includes Massa Medicata Fermentata, Hordei Fructus Germinatus, Pinelliae Rhizoma, Raphani Semen, and Bambusae Caulis in Taenias. The third group includes Poria, Atractylodis Macrocephalae Rhizoma, and Dioscoreae Rhizoma. The fourth group includes Magnoliae Officinalis Cortex, Atractylodis Rhizoma, Pogostemonis Herba, Coptidis Rhizoma, Scutellariae Radix, and Coicis Semen. The fifth group includes Forsythiae Fructus, Taraxaci Herba, Bupleuri Radix, Fritillariae Thunbergii Bulbus, Prunellae Spica, and Ostreae Concha. Conclusion: The basic therapeutic principles of LIU's TCM pediatrics in treating children with FAP are regulating the liver and spleen, and regulating qi to alleviate pain. According to the differences in syndrome manifestations,methods such as promoting digestion and resolving stagnation,replenishing qi and strengthening the spleen,clearing heat and resolving dampness, and detoxifying and resolving masses can be used respectively.

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董洋,陈朝阳,莫蕊辰,于晨,任雪,葛慧,张敏青,张慧敏.基于数据挖掘技术分析济南刘氏中医儿科治疗儿童功能性腹痛用药规律[J].新中医,2025,57(21):18-24

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  • 在线发布日期: 2025-11-11
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