Abstract： Objective： To observe the curative effect of modified Sihe Decoction for chronic gastritis of cold congealing and collateral stasis type. Methods：A total of 80 cases of patients with chronic gastritis of cold congealing and collateral stasis type，who received treatment at the Gastroenterology Outpatient Department of Yongkang Hospital of Traditional Chinese Medicine from January to December 2023，were selected and divided into the control group and the observation group according to the random number table method，with 40 cases in each group. No patients were lost to follow-up or excluded. The observation group was treated with modified Sihe Decoction，and the control group was treated with Omeprazole Enteric-Coated Capsules. Both groups were treated for four weeks. The levels of pepsinogen （PG）-Ⅰ， PG-Ⅱ， and gastrin-17（G-17）in serum， Short Form Health Survey（SF-36）scores， and traditional Chinese medicine syndrome scores before and after treatment as well as clinical effects and incidence of adverse reactions were compared between the two groups. Results：After treatment，the total effective rate was 95.0%（38/40） in the observation group，significantly higher than that of 60.0%（24/40）in the control group（P＜0.05）. Traditional Chinese medicine syndrome scores for epigastric pain，epigastric distension and fullness，fear of cold，lassitude and weakness，cold limbs，and loose stools，as well as total scores in the two groups were decreased when compared with those before treatment（P＜0.05）. The observation group had lower traditional Chinese medicine syndrome scores mentioned above and total scores compared to the control group（P＜0.05）.The serum PG-Ⅰ and G-17 levels of both groups were increased compared with those before treatment（P＜0.05），and the serum PG-Ⅰ and G-17 levels of the observation group were higher than those of the control group（P＜0.05）； the serum PG- Ⅱ levels of both groups decreased compared with those before treatment（P＜0.05），and the serum PG-Ⅱ level of the observation group was lower than that of the control group（P＜0.05）. The scores of SF-36 dimensions， including role-physical， physical functioning， bodily pain， role-emotional， social functioning， vitality， mental health， and general health， were significantly higher in both groups than those before treatment. Moreover，the scores of the above eight dimensions in the observation group were all higher than those in the control group（P＜0.05）.During the treatment period，there was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups（P＞ 0.05）. Conclusion：Modified Sihe Decoction for chronic gastritis of cold congealing and collateral stasis type has a good curative effect，which can alleviate symptoms，promote repair of gastric mucosa and enhance quality of life，with good safety.