补肾安胎膏治疗肾虚血瘀型抗磷脂综合征复发性流产临床研究
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R714.21

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山东省潍坊市中医药科研项目(WFZYY2024-3-030)


Clinical Study on Bushen Antai Soft Extract for Recurrent Miscarriage in Antiphospho⁃ lipid Syndrome of Kidney Deficiency and Blood Stasis Type
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    摘要:

    目的:观察补肾安胎膏治疗肾虚血瘀型抗磷脂综合征(APS) 复发性流产的临床疗效。方法:选 择2022 年1 月—2024 年6 月于寿光市中医医院妇产科门诊及住院治疗的肾虚血瘀型APS 复发性流产患者 120例,均为宫内早期妊娠状态,按随机数字表法分为观察组和对照组各60例。对照组给予低分子肝素钠注射 液皮下注射和地屈孕酮口服,观察组在对照组基础上予补肾安胎膏口服,2组均治疗至妊娠12周。评价2组临 床疗效,比较2组中医证候评分、子宫动脉血血流情况、血浆D-二聚体水平及血清人绒毛膜促性腺激素β亚单 位(β-HCG)、孕酮(P)、雌二醇(E2) 水平,统计治疗后2 组的抗体转阴率。结果:观察组总有效率为 93.33%(56/60),高于对照组78.33%(47/60),差异有统计学意义(P<0.05)。治疗后,2组中医证候积分较 治疗前降低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗至孕10周,2组β-HCG、P、E2 水平较治疗前升高(P<0.05);且观察组β-HCG、P、E2水平高于对照组(P<0.05)。治疗后,2组D-二聚体 水平较治疗前降低(P<0.05);且观察组D-二聚体水平低于对照组(P<0.05)。治疗后,2组子宫动脉收缩期 最大血流速度与舒张末期血流速度的比值(S/D)、搏动指数(PI)、阻力指数(RI) 较治疗前降低(P<0.05); 且观察组S/D比值、PI、RI低于对照组(P<0.05)。治疗后,观察组抗体转阴率为81.67%(49/60),高于对照 组63.33%(38/60),差异有统计学意义(P<0.05)。结论:补肾安胎膏治疗肾虚血瘀型APS复发性流产患者保 胎疗效确切,可以改善孕后性激素水平,通过调节免疫、增加子宫动脉血供,提高保胎成功率,减少患者反复 流产的发生。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Bushen Antai Soft Extract in treating recurrent miscarriage in antiphospholipid syndrome(APS)of kidney deficiency and blood stasis type. Methods: A total of 120 APS patients with recurrent miscarriage of kidney deficiency and blood stasis type, all in early intrauterine pregnancy, were selected from the outpatient and inpatient departments of gynecology and obstetrics at Shouguang Hospital of Traditional Chinese Medicine between January 2022 and June 2024. They were divided into the observation group and the control group according to the random number table method, with 60 cases each. The control group received subcutaneous injections of low-molecular-weight heparin sodium and oral dydrogesterone, while the observation group was additionally given Bushen Antai Soft Extract orally. Both groups were treated until the 12th week of pregnancy. Clinical efficacy was evaluated, and comparisons were made between the two groups regarding traditional Chinese medicine syndrome scores, uterine artery blood flow, plasma D-dimer levels, serum β-human chorionic gonadotropin(β-HCG),progesterone(P),estradiol(E2)levels,and antibody seroconversion rates after treatment. Results:The total effective rate in the observation group was 93.33%(56/60),higher than the 78.33%(47/60)in the control group, the difference being significant(P<0.05). After treatment, traditional Chinese medicine syndrome scores decreased in both groups(P<0.05), with the observation group showing lower scores than the control group (P<0.05). By the 10th week of pregnancy,β-HCG,P,and E2 levels increased in both groups compared with pretreatment levels(P<0.05),with the observation group exhibiting higher levels than the control group(P<0.05). After treatment,D-dimer levels decreased in both groups(P<0.05),with the observation group showing lower levels than the control group(P<0.05). Additionally, the systolic-to-diastolic ratio(S / D), pulsatility index(PI), and resistance index(RI)of uterine artery blood flow decreased in both groups(P<0.05), with the observation group demonstrating lower values than the control group(P<0.05). The antibody seroconversion rate in the observation group was 81.67%(49 / 60), significantly higher than the 63.33%(38 / 60)in the control group, the difference being significant(P<0.05). Conclusion:Bushen Antai Soft Extract is effective in preventing miscarriage in APS patients of kidney deficiency and blood stasis type. It improves post-pregnancy sex hormone levels,regulates immunity,enhances uterine artery blood supply, increases the success rate of pregnancy maintenance, and reduces the occurrence of recurrent miscarriage.

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丁倩倩,韩佳佳,张继广,王爱霞.补肾安胎膏治疗肾虚血瘀型抗磷脂综合征复发性流产临床研究[J].新中医,2025,57(21):72-77

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  • 在线发布日期: 2025-11-11
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