Abstract： Objective： To observe the clinical efficacy of warming-needle moxibustion combined with point application in the treatment of knee osteoarthritis（KOA）based on the theory of strengthening yang. Methods：A total of 90 KOA patients treated in the Department of Acupuncture and Moxibustion of Lishui people's Hospital from June 2023 to June 2024 were selected and divided into the control group（42 cases）and the observation group（48 cases） according to the difference of treatment schemes. On the basis of conventional western medicine treatment，the control group was treated with point application， and the observation group was treated with warming-needle moxibustion combined with point application. The clinical efficacy and incidence of adverse reactions were compared between the two groups， and the changes in traditional Chinese medicine syndrome scores， Lysholm knee scores， immune inflammation index values [transforming growth factor-β（TGF-β），interferon-γ（IFN-γ），and insulin-like growth factor-1（IGF-1）]，Toll-like receptor 4（TLR4）/nuclear factor kappa B（NF-κB）pathway，bone metabolism index values [osteocalcin（BGP），bone specific alkaline phosphatase（BALP），and osteoprotegerin（OPG）] were compared between the two groups before and after treatment. Results：After treatment，the total effective rate was 93.75%（45/ 48）in the observation group，while that of 76.19%（32/42）in the control group，the difference being significant（P＜ 0.05）. After treatment， the traditional Chinese medicine syndrome scores of joint dull pain， limited flexion and extension，cold limbs，soreness and weakness of waist and knees，and mental fatigue in the two groups were decreased compared with those before treatment（P＜0.05），and the Lysholm scores were increased compared with those before treatment（P＜0.05）. The traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group（P＜0.05）， and the Lysholm score was higher than that in the control group（P＜0.05）. After treatment，the levels of IFN-γ，TLR4 protein and NF-κB protein in the two groups decreased compared with those before treatment（P＜0.05），and the levels of IGF-1 and TGF - β increased compared with those before treatment（P＜ 0.05）. The levels of IFN-γ， TLR4 protein and NF-κB protein in the observation group were lower than those in the control group（P<0.05），and the levels of IGF-1 and TGF-β in the observation group were higher than those in the control group（P＜0.05）. After treatment， the index values of BGP， BALP and OPG in the two groups increased compared with those before treatment（P＜0.05），and the above three index values in the observation group were higher than those in the control group（P＜0.05）. The incidence of adverse reactions was 4.17%（2/48）in the observation group and 7.14%（3/42）in the control group， and there was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： Warming-needle moxibustion combined with point application based on the theory of strengthening yang has a good clinical effect in the treatment of KOA， which can effectively relieve the clinical symptoms such as joint pain， inhibit inflammatory responses， regulate the balance of bone metabolism，and promote the recovery of joint function，with high safety.