Abstract：Objective：To observe the clinical efficacy of Shugan Jieyu Anshen Granules combined with auricular point therapy in treating coronary heart disease（CHD）complicated by depression with liver qi stagnation syndrome. Methods：A total of 102 patients with CHD complicated by depression with liver qi stagnation syndrome treated in the CardiacCenterofTheFirstAffiliatedHospitalofHenanUniversityofChineseMedicinefromJune 2024toFebruary2025were selected and divided into a trial group and a control group using a random number table method，with 51 cases in each group. No patients were excluded in either group. The control group received oral Flupentixol and Melitracen Tablets， while the trial group received Shugan Jieyu Anshen Granules combined with auricular point therapy. Both groups were treated for eight weeks. Clinical efficacy，traditional Chinese medicine syndrome scores，neurotransmitter levels，and quality of life before and after treatment，as well as safety during treatment，were compared between the two groups. Results：After treatment，the total effective rate was 92.16%（47/51）in the trial group，higher than that of 76.47% （39/51）in the control group（P＜0.05）. Scores of the 9-item Patient Health Questionnaire（PHQ-9）， Self-Rating Depression Scale（SDS）， and traditional Chinese medicine syndrome scores decreased in both groups compared with those before treatment（P＜0.05）， and the trial group had lower PHQ-9， SDS， and traditional Chinese medicine syndrome scores than the control group（P＜0.05）. Levels of 5-hydroxytryptamine（5-HT）and dopamine（DA），and Seattle Angina Questionnaire（SAQ）scores increased in both groups compared with those before treatment（P＜0.05）， and the trial group had higher 5-HT，DA levels，and SAQ scores than the control group（P＜0.05）. During treatment， the incidence of adverse reactions in the trial group was 5.88%（3/51），lower than the control group at 19.61%（10/51） （P＜0.05）. Conclusion：Shugan Jieyu Anshen Granules combined with auricular point therapy is effective in treating CHD complicated by depression with liver qi stagnation syndrome， and can alleviate depressive symptoms， improve quality of life，and regulate neurofunction with good safety.