Abstract：Helicobacter pylori（Hp）infection is a major factor leading to chronic gastritis，and the nuclear factor （NF）-κB signaling pathway plays a key role in the pathogenesis of Hp associated gastritis（HAG）. This article reviews the research progress of Chinese medicine intervention in HAG by regulating the NF-κB signaling pathway. Studies have found that Chinese medicine monomers and compound preparations can regulate the NF-κB signaling pathway through multiple mechanisms，exerting their roles in anti-inflammation，immunoregulation and inhibition of apoptosis. A total of 18 Chinese medicine monomers were included， including flavonoids， phenols， alkaloids， polysaccharides and terpenoids，as well as 11 Chinese medicine preparations. These Chinese medicine primarily act through signaling pathways of interleukin-1 receptor-associated kinase 4（IRAK4）/inhibitor of NF-κB α（IκBα）/NF-κB， Toll-like receptor 4 （TLR4）/NF-κB，protein kinase B（Akt）/NF-κB，myeloid differentiation primary response protein 88（MyD88）/NF-κB， Toll-like receptor 2（TLR2）/MyD88/NF-κB，high mobility group box 1 protein（HMGB1）/NF-κB，mitogen-activated protein kinase（MAPK）/NF-κB，and TLR4/NF-κB/Nucleotide-binding digomerization domain-like receptor protein 3 （NLRP3）. Although Chinese medicine shows potential in treating HAG，the systematic screening and identification of components in Chinese medicine still has a long way to go，and the clinical evidence on the curative effect and safety of Chinese medicine intervention in HAG remains insufficient. Future research should integrate modern biotechnology to further elucidate the mechanisms of components from Chinese medicine in regulating the NF-κB signaling pathway， providing more effective strategies for HAG treatment.