Abstract： Objective： To analyze the medication patterns of Chinese medicine in treating osteomyelitis through literature data mining and to investigate the action targets of core medicine using network pharmacology. Methods： Literature on Chinese medicine treatment of osteomyelitis published from the inception of the databases to March 1， 2025， was retrieved from CNKI， Wanfang， VIP， PubMed， Embase， and Web of Science. Full-text reading was performed to extract Chinese medicine prescription data. Excel， Python， Cytoscape 3.10.3， and SPSS Modeler 18.0 were used for the analyses of Chinese medicine frequency， property， flavor， and meridian tropism， as well as association rule and cluster analyses. The core Chinese medicines obtained were used as research objects. Effective components and targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）and verified via the UniProt database. Disease genes related to osteomyelitis were identified in the GeneCards database and the Online Mendelian Inheritance in Man（OMIM）database，and intersection analysis was conducted to obtain common genes. The core target protein-protein interaction（PPI）network diagram was obtained using Cytoscape. The medicine-disease intersection targets were imported into the Metascape database for Gene Ontology （GO）and Kyoto Encyclopedia of Genes and Genomes（KEGG）enrichment analyses. Results：A total of 246 articles were included，with 249 prescriptions，204 Chinese medicines，and 32 categories. The most common categories were qi-tonifying， heat - clearing and detoxifying， and blood-tonifying and blood-activating and analgesic medicines. The medicine properties were mainly warm，cold，and neutral，with sweet，bitter，and pungent flavors predominating. The meridian tropism was primarily to the liver，spleen，and lung meridians. Association rule analysis revealed the strongest associationsbetweenTaraxaciHerba-LoniceraeJaponicaeFlos，Atractylodis Macrocephalae Rhizoma - Astragali Radix， and Codonopsis Radix - Astragali Radix. Cluster analysis yielded five groups of prescriptions. Using "Angelicae Sinensis Radix - Lonicerae Japonicae Flos - Glycyrrhizae Radix et Rhizoma - Astragali Radix" as the core drugs，137 active ingredients and 242 corresponding targets were obtained. These were intersected with 11 888 targets related to osteomyelitis， resulting in 217 overlapping targets. GO analysis of the overlapping targets revealed significant enrichment in biological processes such as responses to organic cyclic compounds and xenobiotic stimulus； cellular components including membrane rafts and membrane microdomains; and molecular functions such as ubiquitin-like protein ligase binding and kinase binding. KEGG pathway enrichment analysis primarily identified pathways related to cancer，lipid and atherosclerosis，as well as transcriptional misregulation in cancer. Three key active ingredients were identified，namely quercetin，stigmasterol，and glycyrol. Additionally，core targets such as prostaglandin-endoperoxide synthase 2（PTGS2），tumor necrosis factor（TNF），interleukin-6（IL-6），AKT serine/threonine kinase 1（AKT1）， and signal transducer and activator of transcription 3 （STAT3） were identified. Molecular docking validation demonstrated that the binding energies between the key active ingredients and the core targets were all less than -5 kcal/ mol. Conclusion： The etiology and pathogenesis of osteomyelitis involves heat-toxin accumulation， qi and blood deficiency，blood stasis，and liver and kidney deficiency. The basic treatment principles are to treat both the root and the branch of the disease and to reinforce the healthy qi while dispelling pathogenic factors. The treatment methods include heat-clearing and detoxifying，blood-activating and stasis-removing，qi-tonifying and blood-nourishing，and liver and kidney-tonifying. The core medicine may act on targets such as TNF， IL6， AKT1， and STAT3 through componentslike quercetin，stigmasterol，glycyrol，and kaempferol，thereby intervening in the generation of inflammatory factors，affecting osteoblast differentiation，and regulating angiogenesis to exert therapeutic effects on osteomyelitis.