Abstract： Objective： To analyze the mechanism of Gegen Jianghuang Powder in treating hypertension through network pharmacology，with preliminary validation via molecular docking and dynamics simulations. Methods：Based on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP）and UniProt data platform， the chemical constituents of Gegen Jianghuang Powder were comprehensively searched and the target prediction was carried out. The data set of hypertension related targets was constructed by integrating the four major disease target databases of On-line Mendelian Inheritance in Man（OMIM）， GeneCards database， DrugBank and Therapeutic Target Database（TTD）. After the drug-disease common targets were screened by Venn diagram， the protein-protein interaction（PPI）network was constructed by using STRING database，and the key core targets were identified by topological parameters. The Metascape analysis platform was further used to implement Gene Ontology （GO）function annotation and Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway enrichment analyses for core targets. Finally，AutoDock software was used for molecular docking to verify the ligand receptor binding activity， and the stability of the core component and core target binding model was verified by molecular dynamics simulation. Results： The core components of Gegen Jianghuang Powder in the treatment of hypertension were β - sitosterol， stigmasterol，formononetin and campesterol. The core targets mainly included prostaglandin G/H synthase 2（PTGS2）， peroxisomeproliferator-activatedreceptor γ（PPARG），estrogenreceptor 1（ESR1），nitricoxidesynthase 3（NOS3），etc. The KEGG pathway enrichment mainly included calcium signaling pathway， neuroactive ligand-receptor interaction pathway，estrogen signaling pathway，etc. The results of molecular docking showed that the core active components of Gegen Jianghuang Powder could be well combined with key targets. Molecular dynamics simulation further confirmed that campesterol with the best energy binding had good binding activity with PTGS2. Conclusion：Gegen Jianghuang Powder may regulate calcium signal transduction， lipid metabolism pathway and alleviate oxidative stress injury by acting on PTGS2， PPARG， ESR1， NOS3 and other core targets through key components such as β -sitosterol， stigmasterol，formononetin and campesterol.