基于数据挖掘技术分析专利中药复方治疗阿尔茨海默病用药规律
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R749.16

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国家重点研发计划项目(2022YFC3501402)


Analysis on Medication Rules of Patented Chinese Herbal Compounds for Alzheimer's Disease Based on Data Mining Techniques
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    摘要:

    目的:通过数据挖掘技术分析专利中药复方治疗阿尔茨海默病的用药规律。方法:收集中国学术 期刊数据库(万方期刊) 专利数据库、广州中医药大学资源库——研知科研支持数据库中治疗阿尔茨海默病的 专利中药复方数据,利用古今医案云平台、R语言等软件进行频数统计、关联规则分析、聚类分析等数据分 析,挖掘中药复方治疗阿尔茨海默病的用药特点和组方规律,并实现网络可视化。结果:共纳入388首专利复 方,涉及药物605味,高频中药前5位为:石菖蒲、远志、川芎、黄芪、人参。药性以温药为主,药味以甘味 为主,主要归肝、肾经,药物功效以润肠通便、安神益智为主。最终获得75条关联规则,其中2种药物关联规 则13条,3种药物关联规则54条,4种药物关联规则8条。经聚类分析,获得4类药物组合,其主要功效为, C1:益气活血、安神益智;C2:祛风止痛、补肾壮阳;C3:补气健脾;C4:生津养血、润肠通便。结论:专 利中药复方治疗阿尔茨海默病的高频药物为石菖蒲、远志、川芎、黄芪、人参,以补益气血、化痰祛瘀、开窍 益智药物为主,表明阿尔茨海默病致病与虚、痰、瘀密切相关。

    Abstract:

    Abstract: Objective: To analyze the medication rules of patented Chinese herbal compounds for Alzheimer's disease based on data mining. Methods:The patent data on Chinese herbal compounds for Alzheimer's disease in the patent database of China Science Periodical Database(Wanfang)and the resource database of Guangzhou University of Chinese Medicine-NeoSCI were collected. The frequency statistics, association rule analysis, cluster analysis and other data analysis were carried out by using the Ancient and Modern Medical Case Cloud Platform, R language and other software to explore the medication characteristics and prescription patterns of Chinese herbal compounds for Alzheimer's disease,and realize the network visualization. Results:A total of 388 patented compound prescriptions were included, involving 605 Chinese medicines. The top five were Acori Tatarinowii Rhizoma, Polygalae Radix, Chuanxiong Rhizoma,Astragali Radix and Ginseng Radix et Rhizoma. They are mainly warm in nature,and sweet in flavor,with main meridian entries to the liver and kidney. They are mainly used to moisten the intestines and promote defecation,tranquilize the mind and improve intelligence. Finally,75 association rules were obtained,including 13 items of 2 Chinese medicines,54 items of 3 Chinese medicines and 8 items of 4 Chinese medicines. Through cluster analysis, 4 kinds of medicinal combinations were obtained, and their main effects were as follows: C1: nourishing qi and activating blood,and tranquilizing the mind and improving intelligence;C2:dispelling wind and relieving pain,and tonifying the kidney and strengthening yang; C3: tonifying qi and invigorating spleen; C4: producing fluid and nourishing blood,and moistening the intestines and promoting defecation. Conclusion:The high-frequency Chinese medicines for Alzheimer's disease in patented Chinese herbal compounds are Acori Tatarinowii Rhizoma, Polygalae Radix, Chuanxiong Rhizoma, Astragali Radix and Ginseng Radix et Rhizoma, which are mainly for replenishing qi and blood, resolving phlegm and removing blood stasis, and inducing resuscitation and improving intelligence, indicating that the pathogenesis of Alzheimer's disease is closely related to deficiency,phlegm and blood stasis.

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黄梓钿,章惠萍,刘兴华,张叶子,林兴栋.基于数据挖掘技术分析专利中药复方治疗阿尔茨海默病用药规律[J].新中医,2025,57(22):1-7

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  • 在线发布日期: 2025-11-26
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