Abstract： Objective： To analyze the medication rules of the renowned traditional Chinese medicine（TCM） practitioner KE Gan in treating epigastric pain of spleen deficiency and qi stagnation type based on data mining and integrative pharmacology. Methods： Medical records of patients with epigastric pain of spleen deficiency and qi stagnation type treated at the outpatient clinic of the renowned TCM practitioner KE Gan in Taizhou Hospital of Zhejiang Province，from September 2017 to September 2021 were collected. Using the Traditional Chinese Medicine Inheritance Computing System （TCMICS） V3.5 software， the "statistical analysis"， "prescription analysis"， and "symptom analysis" functions of the "data analysis" module were employed to analyze the symptoms and prescription patterns of the included medical records. The results were visually displayed through network visualization. For patients with epigastric pain of various syndromes， integrative pharmacological analysis of drug combinations was conducted using the Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine（TCMIP）V2.0 platform，based on drug frequency and core drug combinations，to identify potential regular prescriptions. Results：A total of 500 medical records were collected， involving 67 Chinese herbal medicines. ① Syndrome correlation： Epigastric pain of spleen deficiency and qi stagnation type（500 cases）was highly correlated with the pathogenesis of liver-spleen disharmony， with a higher proportion of female patients（353/500）， and was closely related to emotional factors（such as liver depression）. ② Medication rules：The top three most frequently used Chinese herbal medicines were Poria（411 times）， Citri Sarcodactylis Fructus（383 times）， and Endoconcha Sepiae（381 times）. The four properties of Chinese herbal medicine were predominantly warm， the five flavors were mostly bitter， and the meridian tropism was primarily the spleen meridian. ③ Treatment characteristics： The method of soothing the liver and strengthening the spleen （500 times）was dominant， supplemented by regulating qi（1 236 times）and tonifying deficiency（855 times）， reflecting the approach of simultaneously regulating the liver and spleen. ④ Pharmacological mechanisms： Highfrequency drug combinations（e. g.， Poria-Citri Sarcodactylis Fructus） exert anti-inflammatory， anti-ulcer， and sedative effects by regulating targets such as pepsin and serotonin. Conclusion：The potential regular prescriptions of the renowned TCM practitioner KE Gan for treating epigastric pain of spleen deficiency and qi stagnation type mainly include Poria，Endoconcha Sepiae，Fritillariae Thunbergii Bulbus，Citri Sarcodactylis Fructus，Rosae Rugosae Flos， Mume Flos， Codonopsis Radix， stir-fried Paeoniae Radix Alba， stir-fried Atractylodis Macrocephalae Rhizoma， Corydalis Rhizoma，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，and Citri Reticulatae Pericarpium.