膝骨关节炎中医症状-证候-用药规律分析与可视化网络构建研究
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R274

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湖南省重点研发计划项目(2024JK2130)


Research on Analysis of Traditional Chinese Medicine Symptoms, Syndromes, and Medication Rules in Knee Osteoarthritis and Construction of a Visual Network
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    摘要:

    目的:基于数据挖掘技术分析膝骨关节炎(KOA) 中医症状-证候-用药规律,并构建可视化网 络,为临床诊疗提供依据。方法:检索中国知识资源总库(CNKI)、万方数据知识服务平台(WanFang)、维普 中文期刊服务平台(VIP) 和中国生物医学文献服务系统(SinoMed) 自建库至2024年12月31日发表的中药口 服方剂治疗KOA的临床研究文献,整理并建立数据库。运用Excel 2019、SPSS Modeler18.0及SPSS Statistics27.0 软件统计症状、中医证型、中药功效和性味归经,采用Cytoscape3.7.2构建可视化网络,分析用药规律。结果: 共纳入462篇文献,包含563首处方、60种单一证型、63种复合证型、364种症状以及294味中药。高频症状 有膝关节疼痛、肿胀、脉细等;常见中医证型有肝肾亏虚证、寒湿痹阻证、风寒湿痹阻证等;高频中药有牛 膝、当归、熟地黄等。中药药性以温为多,药味以辛、甘、苦为主,多入肝、肾、脾、心经,中药功效以补 虚、祛风湿、活血化瘀药为主。中药聚类分析得到7大核心组合,主要体现了活血化瘀、祛风除湿、补肾壮骨 及温阳散寒等功效。复杂网络分析构建出“症状-证候-中药”多维关联网络,揭示了三者间存在多层次、强 关联的作用关系,并总结出3个常见证型。肝肾亏虚证以膝关节隐痛、腰膝酸软为主症,多用牛膝、熟地黄等 补益肝肾;寒湿痹阻证以关节重痛、遇冷加剧为特征,多用桂枝、独活等散寒除湿;风寒湿痹阻证以关节肿 胀、酸痛重着为特点,多用独活、防风等祛风散寒。结论:KOA病机属本虚标实,病位在筋骨,与肝、肾、 脾密切相关。其症状与证候紧密相关,且用药随证候而异。中医治疗以辨证为核心,在祛风、散寒、除湿、活 血以治标的同时,重视补肝肾、强筋骨以固其本。本研究通过数据挖掘与可视化网络构建,系统揭示了症状- 证候-中药间的内在联系,为KOA的临床辨证及遣方用药提供重要参考。

    Abstract:

    Abstract: Objective: To analyze the traditional Chinese medicine (TCM) symptoms, syndromes, and medication rules of knee osteoarthritis(KOA)based on data mining technology, and to construct a visual network to provide evidence for clinical diagnosis and treatment. Methods:Clinical research literature on oral TCM formulas for treating KOA published from the inception of each database until December 31,2024,was retrieved from the China National Knowledge Infrastructure(CNKI), WanFang Data Knowledge Service Platform(WanFang), VIP Chinese Journal Service Platform(VIP), and SinoMed. The data was collated and a database was established. Excel 2019, SPSS Modeler18.0, and SPSS Statistics27.0 were used to analyze symptoms, TCM syndrome types, Chinese herbal effects, and nature, flavor, channel entry. Cytoscape3.7.2 was employed to construct visual networks and analyze medication rules. Results: A total of 462 articles were included, containing 563 prescriptions, 60 single syndrome types, 63 compound syndrome types, 364 symptoms, and 294 Chinese herbs. High-frequency symptoms included knee joint pain, swelling, thready pulse, etc. Common TCM syndrome types included liver-kidney deficiency syndrome, cold-dampness impediment and obstruction syndrome, wind-cold-dampness impediment and obstruction syndrome. High-frequency herbs included Achyranthis Bidentatae Radix,Angelicae Sinensis Radix,and Rehmanniae Radix Praeparata. Herbal natures were predominantly warm; flavors were mainly acrid, sweet, and bitter; herbs primarily entered the liver, kidney, spleen, and heart channels; herbal effects were mainly supplementing deficiency,dispelling wind-damp,and invigorating blood and removing stasis. Cluster analysis of herbs yielded seven core combinations, primarily reflecting the effects of invigorating blood and removing stasis, dispelling wind and dampness, supplementing the kidney and strengthening bones, and warming yang and dispersing cold. Complex network analysis constructed a multi-dimensional association network of "symptoms-syndromes-Chinese herbs", revealing multi-level and strongly correlated relationships among them,and summarized three common syndrome types. Liver-kidney deficiency syndrome,characterized by dull knee pain and soreness and weakness of the lower back and knees, commonly used Achyranthis Bidentatae Radix and Rehmanniae Radix Praeparata to supplement and boost the liver and kidney. Cold-dampness impediment and obstruction syndrome,characterized by heavy joint pain aggravated by cold, commonly used Cinnamomi Ramulus and Angelicae Pubescentis Radix to disperse cold and eliminate dampness. Wind-cold-dampness impediment and obstruction syndrome, characterized by joint swelling, soreness, and heaviness,commonly used Angelicae Pubescentis Radix and Saposhnikoviae Radix to dispel wind and scatter cold. Conclusion:The pathogenesis of KOA involves deficiency in origin and excess in superficiality. The disease location is in the tendons and bones, closely related to the liver, kidney, and spleen. Its symptoms are closely correlated with syndromes, and medication rules varies according to the syndrome. TCM treatment is centered on syndrome differentiation,focusing on dispelling wind,scattering cold,eliminating dampness,and invigorating blood to address the superficiality,while also emphasizing supplementing the liver and kidney and strengthening tendons and bones to secure the root. This study, through data mining and the construction of a visual network, systematically reveals the intrinsic relationships among symptoms, syndromes, and Chinese herbs, providing an important reference for the clinical syndrome differentiation and prescription of medication for KOA.

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周宜琳,刘迈兰,刘伟.膝骨关节炎中医症状-证候-用药规律分析与可视化网络构建研究[J].新中医,2025,57(22):20-27

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  • 在线发布日期: 2025-11-26
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