Research on Analysis of Traditional Chinese Medicine Symptoms, Syndromes, and Medication Rules in Knee Osteoarthritis and Construction of a Visual Network
Abstract: Objective: To analyze the traditional Chinese medicine (TCM) symptoms, syndromes, and medication rules of knee osteoarthritis(KOA)based on data mining technology, and to construct a visual network to provide evidence for clinical diagnosis and treatment. Methods:Clinical research literature on oral TCM formulas for treating KOA published from the inception of each database until December 31,2024,was retrieved from the China National Knowledge Infrastructure(CNKI), WanFang Data Knowledge Service Platform(WanFang), VIP Chinese Journal Service Platform(VIP), and SinoMed. The data was collated and a database was established. Excel 2019, SPSS Modeler18.0, and SPSS Statistics27.0 were used to analyze symptoms, TCM syndrome types, Chinese herbal effects, and nature, flavor, channel entry. Cytoscape3.7.2 was employed to construct visual networks and analyze medication rules. Results: A total of 462 articles were included, containing 563 prescriptions, 60 single syndrome types, 63 compound syndrome types, 364 symptoms, and 294 Chinese herbs. High-frequency symptoms included knee joint pain, swelling, thready pulse, etc. Common TCM syndrome types included liver-kidney deficiency syndrome, cold-dampness impediment and obstruction syndrome, wind-cold-dampness impediment and obstruction syndrome. High-frequency herbs included Achyranthis Bidentatae Radix,Angelicae Sinensis Radix,and Rehmanniae Radix Praeparata. Herbal natures were predominantly warm; flavors were mainly acrid, sweet, and bitter; herbs primarily entered the liver, kidney, spleen, and heart channels; herbal effects were mainly supplementing deficiency,dispelling wind-damp,and invigorating blood and removing stasis. Cluster analysis of herbs yielded seven core combinations, primarily reflecting the effects of invigorating blood and removing stasis, dispelling wind and dampness, supplementing the kidney and strengthening bones, and warming yang and dispersing cold. Complex network analysis constructed a multi-dimensional association network of "symptoms-syndromes-Chinese herbs", revealing multi-level and strongly correlated relationships among them,and summarized three common syndrome types. Liver-kidney deficiency syndrome,characterized by dull knee pain and soreness and weakness of the lower back and knees, commonly used Achyranthis Bidentatae Radix and Rehmanniae Radix Praeparata to supplement and boost the liver and kidney. Cold-dampness impediment and obstruction syndrome,characterized by heavy joint pain aggravated by cold, commonly used Cinnamomi Ramulus and Angelicae Pubescentis Radix to disperse cold and eliminate dampness. Wind-cold-dampness impediment and obstruction syndrome, characterized by joint swelling, soreness, and heaviness,commonly used Angelicae Pubescentis Radix and Saposhnikoviae Radix to dispel wind and scatter cold. Conclusion:The pathogenesis of KOA involves deficiency in origin and excess in superficiality. The disease location is in the tendons and bones, closely related to the liver, kidney, and spleen. Its symptoms are closely correlated with syndromes, and medication rules varies according to the syndrome. TCM treatment is centered on syndrome differentiation,focusing on dispelling wind,scattering cold,eliminating dampness,and invigorating blood to address the superficiality,while also emphasizing supplementing the liver and kidney and strengthening tendons and bones to secure the root. This study, through data mining and the construction of a visual network, systematically reveals the intrinsic relationships among symptoms, syndromes, and Chinese herbs, providing an important reference for the clinical syndrome differentiation and prescription of medication for KOA.