基于痰瘀互结-窠囊阻滞理论应用二陈汤合知柏地黄汤加减治疗女童特发性中枢性性早熟临床研究
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R725.8

基金项目:

余姚市科技计划项目(2025YZYB01)


Clinical Study on Modified Erchen Decoction Combined with Zhibai Dihuang Decoc⁃ tion for Idiopathic Central Precocious Puberty in Girls Based on Phlegm-Stasis Inter⁃ mingling and Kenang-Obstruction Theory
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:基于痰瘀互结-窠囊阻滞理论应用二陈汤合知柏地黄汤化裁治疗女性儿童特发性中枢性性早 熟(ICPP) 的临床疗效。方法:选取2023 年1 月—2025 年1 月余姚市中医医院儿科门诊收治的120 例女童 ICPP开展研究,按照随机数字表法分为观察组和对照组各60例。观察组给予二陈汤合知柏地黄汤加减治疗, 对照组仅让患儿避免接触含外源性雌激素的食品或用品,以降低环境因素对疾病的影响。比较2组临床疗效、 骨龄(BA) 与实际年龄(CA) 的比值、性激素指标[促卵泡生成素(FSH)、黄体生成素(LH) 以及雌二醇 (E2)] 水平以及卵巢体积变化。结果:治疗后,观察组总有效率为90.00% (54/60),对照组为58.33% (35/ 60),2组比较,差异有统计学意义(P<0.05)。治疗后,2组BA/CA值均较治疗前降低,且观察组BA/CA值低 于对照组,差异均有统计学意义(P<0.05)。治疗后,2组子宫容积、卵巢容积、卵泡直径均较治疗前显著缩 小(P<0.05),且观察组3项指标水平均小于对照组(P<0.05)。治疗后,2组FSH、LH和E2水平均较治疗前 下降(P<0.05),且观察组3项指标水平均低于对照组(P<0.05)。结论:二陈汤合知柏地黄汤加减治疗女童 ICPP,通过化痰祛瘀、通调窠囊,滋阴降火、调理冲任的治疗策略,可有效控制患儿第二性征的异常发育, 延缓骨龄的加速成熟,降低性激素水平。

    Abstract:

    Abstract: Objective: To evaluate the clinical efficacy of modified Erchen Decoction combined with Zhibai Dihuang Decoction for idiopathic central precocious puberty(ICPP)in girls based on the phlegm-stasis intermingling and Kenang( a traditional Chinese Medicine terminology , denoting the pathological cysted mass developing from intermingling of phlegm-dampness and blood stasis)-obstruction theory. Methods : A total of 120 female pediatric patients with ICPP treated at Yuyao Hospital of Traditional Chinese Medicine from January 2023 to January 2025 were divided into the observation and the control group using the random number table method,with 60 cases in each group. The observation group received the modified Erchen Decoction combined with Zhibai Dihuang Decoctior, while the control group only avoided exogenous estrogen exposure. Outcomes included clinical efficacy, bone age (BA)/chronological age(CA)ratio, sex hormone levels [follicle-stimulating hormone(FSH), luteinizing hormone (LH),and estradiol(E2)],and ovarian volume changes were compared. Results:After treatment,the total effective rate was 90.00%(54/60)in the observation group and 58.33%(35/60)in the control group, the difference being significant(P<0.05). After treatment, the BA/CA value in the two groups was decreased compared with that before treatment,and the BA/CA value was lower in the observation group than that in the control group,differences being significant(P<0.05). After treatment, the uterine volume, ovarian volume and follicle diameter in the two groups were significantly decreased compared with those before treatment(P<0.05),and the levels of the three indicators in the observation group were lower than those in the control group(P<0.05). After treatment, the levels of FSH, LH and E2 in the two groups were decreased compared with those before treatment(P<0.05),and the levels of the three indicators in the observation group were lower than those in the control group(P<0.05). Conclusion:The modified Erchen Decoction combined with Zhibai Dihuang Decoction effectively controls secondary sexual characteristics development,decelerates bone age advancement,and reduces sex hormone levels through phlegm-resolving,stasiseliminating, Kenang -regulating, yin-nourishing, fire-purging, and regulating the thoroughfare and conception channels mechanisms.

    参考文献
    相似文献
    引证文献
引用本文

李苏曼,茅渊,朱学鑫.基于痰瘀互结-窠囊阻滞理论应用二陈汤合知柏地黄汤加减治疗女童特发性中枢性性早熟临床研究[J].新中医,2025,57(22):34-38

复制
分享
相关视频

文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2025-11-26
  • 出版日期:
文章二维码