Clinical Study on Modified Erchen Decoction Combined with Zhibai Dihuang Decoc⁃ tion for Idiopathic Central Precocious Puberty in Girls Based on Phlegm-Stasis Inter⁃ mingling and Kenang-Obstruction Theory
Abstract: Objective: To evaluate the clinical efficacy of modified Erchen Decoction combined with Zhibai Dihuang Decoction for idiopathic central precocious puberty(ICPP)in girls based on the phlegm-stasis intermingling and Kenang( a traditional Chinese Medicine terminology , denoting the pathological cysted mass developing from intermingling of phlegm-dampness and blood stasis)-obstruction theory. Methods : A total of 120 female pediatric patients with ICPP treated at Yuyao Hospital of Traditional Chinese Medicine from January 2023 to January 2025 were divided into the observation and the control group using the random number table method,with 60 cases in each group. The observation group received the modified Erchen Decoction combined with Zhibai Dihuang Decoctior, while the control group only avoided exogenous estrogen exposure. Outcomes included clinical efficacy, bone age (BA)/chronological age(CA)ratio, sex hormone levels [follicle-stimulating hormone(FSH), luteinizing hormone (LH),and estradiol(E2)],and ovarian volume changes were compared. Results:After treatment,the total effective rate was 90.00%(54/60)in the observation group and 58.33%(35/60)in the control group, the difference being significant(P<0.05). After treatment, the BA/CA value in the two groups was decreased compared with that before treatment,and the BA/CA value was lower in the observation group than that in the control group,differences being significant(P<0.05). After treatment, the uterine volume, ovarian volume and follicle diameter in the two groups were significantly decreased compared with those before treatment(P<0.05),and the levels of the three indicators in the observation group were lower than those in the control group(P<0.05). After treatment, the levels of FSH, LH and E2 in the two groups were decreased compared with those before treatment(P<0.05),and the levels of the three indicators in the observation group were lower than those in the control group(P<0.05). Conclusion:The modified Erchen Decoction combined with Zhibai Dihuang Decoction effectively controls secondary sexual characteristics development,decelerates bone age advancement,and reduces sex hormone levels through phlegm-resolving,stasiseliminating, Kenang -regulating, yin-nourishing, fire-purging, and regulating the thoroughfare and conception channels mechanisms.