Abstract：Objective：To observe the clinical effect of the combination use of Jinhuang Powder and manipulation of lactation on mastitis in early lactation period. Methods：A total of 78 patients with mastitis in early lactation period admitted to the Department of general Surgery of Luoyang First People's Hospital from January 2023 to October 2024 were selected and divided into the control group and the Jinhuang Powder group according to the random number table method，with 39 cases in each group. The control group was treated with traditional manipulation of lactation combined with external application of magnesium sulfate solution， and the Jinhuang Powder group was treated with traditional manipulation of lactation combined with external application of Jinhuang Powder. After five days of treatment， the clinical effect， traditional Chinese medicine syndrome scores， relief time of symptoms， lactogenesis time， pain degree [Visual Analogue Scale（VAS）scores of pain]， inflammation indexes [neutrophil percentage（NEUT%）， Creactive protein（CRP）and white blood cell count（WBC）] in the two groups were evaluated，and the lactation profile was evaluated after two weeks of follow-up. Results：After five days of treatment，the total effective rate was 97.44% （38/39）in the Jinhuang Powder group，higher than that of 82.05%（32/39）in the control group，with a statistically significant difference（P＜0.05）. After treatment，the traditional Chinese medicine syndrome scores of milk stasis with lumps，swelling and pain，poor lactogenesis（except for the control group），aversion to cold and fever（except for the control group），soreness of the whole body，headache，thirst and constipation in the two groups were down-regulated when compared with those before treatment（P＜0.05），and the above scores in the Jinhuang Powder group were lower than those in the control group（P＜0.05）. After treatment， the VAS scores in the two groups were reduced when compared with those before treatment（P＜0.05），and the VAS score in the Jinhuang Powder group was lower than that in the control group（P＜0.05）. After treatment，the average time of abatement of fever，disappearance time of painful swollen breast，regression time of lumps and lactogenesis time in the Jinhuang Powder group were shorter than those in the control group（P＜0.05）. After treatment，the levels of NEUT%，CRP and WBC in the two groups dwindled when compared with those before treatment（P＜0.05），and the above three levels in the Jinhuang Powder group were lower than those in the control group（P＜0.05）. After two weeks of follow-up，the exclusive breastfeeding rate was 82.05% （32/39）in the Jinhuang Powder group and 61.54%（24/39）in the control group，the difference being significant（P＜ 0.05）；there was no milk withdrawal in the Jinhuang Powder group，and the milk withdrawal rate was 12.82%（5/39） in the control group， the difference being significant（P＜0.05）. Conclusion： The therapy of Jinhuang Powder combined with manipulation of lactation has a significant curative effect on mastitis in early lactation period，which can effectively promote the improvement of clinical symptoms and pain relief，reduce the inflammatory responses，enhance the exclusive breastfeeding rate and reduce the milk withdrawal rate.