Abstract：Objective：To observe the clinical effect of the combination use of wet compress of Piyan Prescription and electrophototherapy on topical corticosteroid dependent dermatitis（TCDD）of damp-heat stagnation type. Methods： A total of 144 TCDD patients of damp-heat stagnation type who were admitted to the Wenzhou TCM Hospital of Zhejiang Chinese Medical University were enrolled and divided into the control group and the trial group by random number table method，with 72 cases in each group. The control group was treated with electrophototherapy，and the trial group was treated with wet compress of Piyan Prescription combined with electrophototherapy. Both groups were treated for four weeks. The clinical effects，scores of subjective symptoms（pain，burning and itching），scores of objective symptoms （erythema，dry with desquamation，telangiectasia and lesion area），skin barrier function [stratum corneum hydration and transepidermal water loss（TEWL）]， inflammation indexes [interleukin-4（IL-4）， interleukin-6（IL-6） and interferon-γ（IFN-γ）] and incidence of adverse reactions were compared between the two groups. Results：After four weeks of treatment，the total clinical effective rate was 93.06%（67/72）in the trial group，which was higher than that of 80.56%（58 / 72） in the control group（P＜0.05）. After two weeks of treatment， the scores of three subjective symptoms and four objective symptoms and TEWL in the two groups were down-regulated when compared with those before treatment（P＜0.05）， and the stratum corneum hydration was up-regulated when compared with that before treatment（P＜0.05）. After four weeks of treatment， the scores of three subjective symptoms and four objective symptoms and TEWL in the two groups were decreased when compared with those after two weeks of treatment（P＜ 0.05），and the stratum corneum hydration was increased when compared with that after two weeks of treatment（P＜ 0.05）. After two and four weeks of treatment，the scores of three subjective symptoms and four objective symptoms and TEWL in the trial group were lower than those at the same period in the control group（P＜0.05）， and the stratum corneum hydration was higher than that at the same period in the control group（P＜0.05）. After four weeks of treatment， the levels of IL-4 and IL-6 in the two groups were decreased when compared with those before treatment（P＜0.05）， and the levels of IFN-γ were increased when compared with those before treatment（P＜0.05）；the levels of IL-4 and IL-6 in the trial group were lower than those in the control group（P＜0.05），and the level of IFN-γ was higher than that in the control group（P＜0.05）. The incidence of adverse reactions was 8.33%（6/72）in the trial group and 5.56% （4/72）in the control group，there being no significance in the difference（P＞0.05）. Conclusion：The combination use of wet compress of Piyan Prescription and electrophototherapy can improve the symptoms and skin barrier function of TCDD patients of damp-heat stagnation type，inhibit the inflammatory response with great safety.