Abstract： Objective： To observe the clinical efficacy of Shuangbu Decoction combined with eye-needling therapy in treating the recovery period of ischemic stroke with qi-deficiency and blood stasis syndrome. Methods：A total of 108 patients in the recovery period of ischemic stroke with qi-deficiency and blood stasis syndrome admitted to the Department of Neurology， Pingyang County Hospital of Traditional Chinese Medicine， from April 2024 to March 2025 were selected and randomly divided into the Shuangbu Decoction group， the eye-needling group， and the combination group （n=36 per group） using a random number table method. The Shuangbu Decoction group received oral Shuangbu Decoction，the eye-needling group received eye-needling therapy，and the combination group received both oral Shuangbu Decoction and eye-needling therapy. All three groups were treated for four weeks continuously. Clinical efficacy was evaluated，and the following parameters were compared among the three groups before and after treatment： neurological deficit [National Institutes of Health Stroke Scale （NIHSS）]， quality of life and motor function [Strokespecific Quality of Life Scale （SS-QOL） ， Barthel Index （BI） ， and Fugl-Meyer Assessment （FMA）]， hemorheology （hematocrit， fibrinogen， and platelet aggregation rate）， serological markers [S100 calcium-binding protein β （S100β），and fibroblast growth factor 23 （FGF23），and brain-derived neurotrophic factor （BDNF）]，and safety （orbital soreness，diarrhea，vomiting，and total incidence）. Results：The total effective rate was 97.22% （35/ 36） in the combination group，higher than 72.22% （26/36） in the Shuangbu Decoction group and 75.00% （27/36） in the eye-needling group （P＜0.05）. After treatment，NIHSS scores decreased in all three groups compared with those before treatment，and the combination group had lower scores than the Shuangbu Decoction group and the eye-needling group （P＜0.05）. After treatment，SS-QOL，BI，and FMA scores increased in all three groups compared with those before treatment， and the combination group had higher scores than the Shuangbu Decoction group and the eyeneedling group （P＜0.05）. After treatment， hematocrit， fibrinogen， and platelet aggregation rate decreased in all three groups compared with those before treatment， and the combination group had lower levels than the Shuangbu Decoction group and the eye-needling group （P＜0.05）. After treatment， S100β and FGF23 levels decreased in all three groups compared with those before treatment， and the combination group had lower levels than the Shuangbu Decoction group and the eye-needling group （P＜0.05）； BDNF levels increased in all three groups compared with those before treatment，and the combination group had higher levels than the Shuangbu Decoction group and the eyeneedling group （P＜0.05）. The incidence of orbital soreness，diarrhea，vomiting，and the total incidence showed no significant differences among the three groups （P＞0.05）. Conclusion： Shuangbu Decoction combined with eyeneedling therapy is effective in treating the recovery period of ischemic stroke with qi-deficiency and blood stasis syndrome. It can promote neurological function recovery，improve hypercoagulability，and is safe.