Abstract：Objective：To observe the clinical effect of the combination use of Xinqin Prescription and Budesonide Nasal Spray on allergic rhinitis （AR）. Methods：A total of 105 AR patients who were admitted to Taishun Hospital of Traditional Chinese Medicine from July 2023 to July 2024 were selected and divided into the group A，the group B and group C according to the random number table method，with 35 cases in each group. The group A was given Budesonide Nasal Spray， the group B was given Xinqin Prescription， and the group C was given the combination use of Xinqin Prescription and Budesonide Nasal Spray. The three groups were treated for four weeks. The clinical effects in the three groups were evaluated， and the Total Nasal Symptom Score （TNSS）， inflammatory indicators， blood routine test indexes and quality of life were compared among the three groups. Results：After treatment，the total clinical effective rate in the group C was higher than that in the group A and the group B （P＜0.05）. After treatment，the TNSS score in the three groups were decreased when compared with those before treatment， and the TNSS score in the group C was lower than that in the group A and the group B （P＜0.05）. After treatment， the levels of inflammatory indicators， including immunoglobulin E （IgE），eosinophil （EOS） and C-reactive protein （CRP） in the three groups were reduced when compared with those before treatment， and the levels of IgE， EOS， and CRP in the group C were lower than those in the group A and the group B （P＜0.05）. After treatment，the levels of blood routine test indexes，including mean corpuscular hemoglobin concentration （MCHC）， hemoglobin （HGB）， monocyte-to-lymphocyte ratio （MLR） and neutrophil-to-lymphocyte ratio （NLR） in the three groups were down-regulated when compared with those before treatment，and the levels of the above four indicators in the group C were lower than those in the group A and the group B （P＜0.05）. After treatment， the scores of Rhinoconjunctivitis Quality of Life Questionnaire （RQLQ） in the three groups were decreased when compared with those before treatment，and the RQLQ score in the group C was lower than that in the group A and the group B （P＜0.05）. Conclusion： The combination use of Xinqin Prescription and Budesonide Nasal Spray can effectively improve the curative effect on AR， which can mitigate the nasal discomfort， reduce the inflammatory responses and significantly enhance the quality of life of patients.