Abstract：Objective：To observe the curative effect of the combination use of external application with midnightmidday ebb flow chrono-Chinese medicine hot package and staged respiratory muscle training on respiratory failure. Methods：A total of 78 patients with respiratory failure admitted to the Second People′s Hospital of Zhoushan from July 2024 to December 2024 were selected and divided into the respiratory training group and the combination group according to the random number table method， with 39 cases in each group. The respiratory training group was given staged respiratory muscle training，and the combination group was additionally given external application with midnightmidday ebb flow chrono-Chinese medicine hot package based on the treatment in the respiratory training group. The changes in blood gas index [partial pressure of oxygen （PaO2）， PaO2/fraction of inspired oxygen （FiO2） and partial pressure of carbon dioxide （PaCO2）]， motor ability index （time for Five Times Sit-to-Stand Test） and scores of modified Medical Research Council Dyspnoea Scale （mMRC） before and after intervention were compared between the two groups. Results： After intervention， the levels of PaO2 and PaO2/FiO2 in the two groups were increased when compared with those before treatment （P＜0.05）， and the PaCO2 levels were decreased when compared with those before treatment （P＜0.05）；the levels of PaO2 and PaO2/FiO2 in the combination group were higher than those in the respiratory training group （P＜0.05），and the PaCO2 level was lower than that in the respiratory training group （P＜ 0.05）. After intervention，the time for Five Times Sit-to-Stand Test and mMRC scores in the two groups were reduced when compared with those before intervention （P＜0.05），and the time for Five Times Sit-to-Stand Test and mMRC score in the combination group were lower than those in the respiratory training group （P＜0.05）. Conclusion： The combination use of external application with midnight-midday ebb flow chrono-Chinese medicine hot package and staged respiratory muscle training has a better intervention effect on patients with respiratory failure， which can effectively improve the lung function of patients， enhance the blood gas parameters and exercise tolerance， and alleviate the symptoms of dyspnea.