Abstract： Objective： To observe the clinical effect of modified Yifei Decoction combined with Salmeterol Xinafoate Aerosol on stable chronic obstructive pulmonary disease of qi-yin deficiency in lung and kidney type. Methods： A total of 136 patients with stable chronic obstructive pulmonary disease of qi-yin deficiency in lung and kidney type who were diagnosed and treated at Wenling TCM Hospital Affiliated to Zhejiang Chinese Medical University from May 2023 to May 2024 were selected as the observation subjects and divided into the control group and the observation group according to the random number table method，with 68 cases in each group. The control group was given inhalation of Salmeterol Xinafoate Aerosol，and the observation group was treated with modified Yifei Decoction based on the treatment in the control group. Both groups were treated for one month. The traditional Chinese medicine syndrome scores， modified Medical Research Council Dyspnea Scale（mMRC） scores， pulmonary function indicators [forced expiratory volume in the first second as a percentage of predicted values （FEV1%）， peak expiratory flow rate （PEF）， inspiratory volume （IC）， ratio of the forced expiratory volume in the first second to the forced vital capacity （FEV1/FVC）， and residual volume to total lung capacity （RV/TLC） ratio] and serum levels of monocyte chemotactic protein 4（MCP-4） and transient receptor potential canonical 6 （TRPC6） before and after treatment，and the clinical effects and incidence of adverse reactions were compared between the two groups. Results：After one month of treatment，the total effective rate in the observation group was higher than that in the control group （P＜0.05）. After treatment，the traditional Chinese medicine syndrome scores of shortness of breath，chest tightness，wheezing in the throat，thick and difficult-to-cough phlegm，fatigue and weakness，spontaneous sweating，wheezing and shortness of breath，soreness and weakness of the waist and knees，and heat in the palms and soles in both groups were decreased when compared with those before treatment， differences being significant （P＜0.05）； the above nine scores in the observation group were lower than those in the control group，differences were significant （P＜0.05）. The mMRC scores in both groups were decreased when compared with those before treatment，differences were significant（ P＜0.05）；the mMRC score in the observation group was lower than that in the control group，differences were significant （P＜0.05）. The FEV1%， PEF， IC， and FEV1/FVC in both groups were increased when compared with those before treatment， and the RV/TLC was decreased when compared with that before treatment，differences being significant（ P＜0.05）. The FEV1%，IC，and FEV1/FVC in the observation group were higher than those in the control group，while the RV/TLC was lower than that in the control group， differences being significant （P＜0.05）. The levels of serum MCP-4 and TRPC6 in both groups were decreased when compared with those before treatment，differences being significant （P＜ 0.05）. The levels of serum MCP-4 and TRPC6 in the observation group were lower than those in the control group， differences being significant （P＜0.05）. There was no significant difference being found in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： The combination use of modified Yifei Decoction and Salmeterol Xinafoate Aerosol can enhance the curative effect on patients with stable chronic obstructive pulmonary disease of qi-yin deficiency in lung and kidney type，which can effectively alleviate the clinical symptoms，improve the pulmonary ventilation function，and reduce the inflammatory responses，with good safety.